Last update 21 Nov 2024

ALS-2158

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Target
NS5B polymerase
Mechanism
NS5B polymerase inhibitors(Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors)
Therapeutic Areas
Infectious DiseasesDigestive System Disorders
Active Indication-
Inactive Indication
Chronic hepatitis C genotype 1
Originator Organization
Alios BioPharma, Inc.Alios BioPharma, Inc.
Active Organization-
Inactive Organization
Alios BioPharma, Inc.Alios BioPharma, Inc.Vertex Pharmaceuticals, Inc.Vertex Pharmaceuticals, Inc.
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Related

2
Clinical Trials associated with ALS-2158
NCT01554085 / TerminatedPhase 1
A Randomized, Double-blind, Placebo-controlled, First-in-human, 3-Part Study of Orally Administered ALS-002158 to Evaluate the Safety, Tolerability and Pharmacokinetics of Single Ascending Dosing and Food-effect in Healthy Volunteers, and Multiple Ascending Dosing in Subjects With Chronic Hepatitis C Genotype 1 Infection
ACTRN12612000176864 / RecruitingPhase 1
A Randomized, Double-blind, Placebo-controlled, First-in-human, 3-Part Study of Orally Administered ALS-002158 to Evaluate the Safety, Tolerability and Pharmacokinetics ofSingle Ascending Dosing and Food-effect in Healthy Volunteers, and Multiple Ascending Dosing in Subjects with Chronic Hepatitis C Genotype 1 Infection.
100 Clinical Results associated with ALS-2158
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100 Translational Medicine associated with ALS-2158
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100 Patents (Medical) associated with ALS-2158
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1
Literatures (Medical) associated with ALS-2158
01 Jun 2014Biochemical PharmacologyQ2 · MEDICINE
Current race in the development of DAAs (direct-acting antivirals) against HCV
Q2 · MEDICINE
100 Deals associated with ALS-2158
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic hepatitis C genotype 1Phase 1
NZ
Vertex Pharmaceuticals, Inc.Vertex Pharmaceuticals, Inc.
31 Dec 2011
Chronic hepatitis C genotype 1Phase 1
AU
Vertex Pharmaceuticals, Inc.Vertex Pharmaceuticals, Inc.
31 Dec 2011
Chronic hepatitis C genotype 1Phase 1
AU
Alios BioPharma, Inc.Alios BioPharma, Inc.
31 Dec 2011
Chronic hepatitis C genotype 1Phase 1
NZ
Alios BioPharma, Inc.Alios BioPharma, Inc.
31 Dec 2011
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Clinical Result

Indication
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Approval

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Regulation

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