Delving into the Latest Updates on Sulukast with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Sulukast (USAN/INN), LY 170680, LY-170680

Target

CysLT

Action

antagonists

Mechanism

CysLT antagonists(Cysteinyl leukotriene receptor antagonists)

Therapeutic Areas

Immune System DiseasesRespiratory Diseases

Active Indication-

Inactive Indication

Asthma

Originator Organization

Eli Lilly & Co.

Active Organization-

Inactive Organization

Eli Lilly & Co.

License Organization-

Drug Highest PhasePendingClinical

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC25H36N4O3S

InChIKeyYPHOSUPSOWQQCB-AFOLHBCXSA-N

CAS Registry98116-53-1

CE is increasingly used in the pharmaceutical industry to sep. and quantify enantiomers of chiral drugs.This article describes the use of CE towards other types of isomerism, namely geometric, that may be present in new drug substances.The ability of CE to sep. and quantify four geometric isomers in a leukotriene antagonist is demonstrated and the resolving power and detectability of CE are compared to two HPLC methods.

01 Jun 1993·Journal of pharmaceutical and biomedical analysisQ3 · MEDICINE

Use of a porous graphitic carbon column to separate cis and trans isomers in a novel anti-asthma compound

Q3 · MEDICINE

Article

Author: Fish, B J

Porous graphitic carbon (PGC) is used to sep. 4 cis-trans isomers of the potential antiasthma agent LY 170680 (I).PGC sep. the isomers more quickly and yields much better HPLC resolution than does ODS-silica.

01 Jan 1991·JOURNAL OF CHROMATOGRAPHY A

Stereochemical analysis of a leukotriene related hydroxypentadecadiene using a chiral high-performance liquid chromatography column and diode array detection

Author: Georgina A. Harvey ; David M. Rackham

A HPLC separation of the chiral isomers of a leukotriene related hydroxypentadecadiene was achieved using a chiral protein column which permits low levels of the undesired distomer to be measured in the eutomer.Diode array and proton magnetic resonance anal. methods were used to confirm their diene stereochem. and that of a related impurity produced in trace amounts in the synthesis.

100 Deals associated with Sulukast

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