Delving into the Latest Updates on Arteether with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Artecef, Artemotil, Artemotil (INN)

+ [11]

Target

Free radicals

Action

stimulants

Mechanism

Free radicals stimulants

Therapeutic Areas

Infectious Diseases

Active Indication

Malaria, Falciparum

Inactive Indication

Toxoplasmosis

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

Netherlands (06 May 2000),

Malaria, Falciparum

Regulation-

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Structure/Sequence

Molecular FormulaC17H28O5

InChIKeyNLYNIRQVMRLPIQ-XQLAAWPRSA-N

CAS Registry75887-54-6

Zika virus (ZIKV) infection can result in severe neurological complications, yet no approved antiviral treatments are currently available. Ginseng, a medicinal herb extensively utilized in Asian traditional medicine, has demonstrated efficacy against various diseases, which has sparked interest in exploring its potential antiviral properties for the treatment of ZIKV.

Methods:

We evaluated the antiviral effects of ginsenoside Rb2 (G-Rb2) in human neuronal cell lines (SK-N-SH and CCF-STTG) and in a lethal ZIKV-infected mouse model. The antiviral efficacy was assessed using bioluminescence imaging with a NanoLuc luciferase reporter ZIKV. In vitro assays were conducted to determine the direct impact of G-Rb2 on ZIKV, while surface plasmon resonance (SPR) was employed to analyze its interaction with ZIKV envelope proteins and viral particles.

Results:

G-Rb2 (200 μM) significantly inhibited ZIKV infection in vitro and protected mice from ZIKV-induced mortality. Bioluminescence imaging validated its antiviral efficacy. In vitro studies demonstrated that incubation with G-Rb2 reduced viral infectivity, and SPR analysis confirmed direct binding between G-Rb2 and ZIKV components.

Conclusion:

G-Rb2 effectively inhibits ZIKV infection both in vitro and in vivo, presumably through direct interaction with viral particles. Given the accessibility of ginseng and its established processing methods, G-Rb2 emerges as a promising candidate for the treatment of ZIKV in humans. Further research is warranted to elucidate its mechanisms of action and evaluate its clinical potential.

01 Jun 2025·Cancer Medicine

ER Stress Induced by Artemisinin and Its Derivatives Determines the Susceptibility to Their Synergistic Apoptotic Killing With TRAIL

Article

Author: Bhowmick, Snigdha ; Lee, Yong J.

ABSTRACT:

Aim:

Artemisinins are a class of antimalarial drugs that are lately being researched for their antitumor activity. We previously reported that artesunate, an artemisinin derivative, can induce ferroptosis and enhance TRAIL (Tumor necrosis factor‐Related Apoptosis‐Inducing Ligand)‐induced apoptosis. Here we investigated the role of endoplasmic reticulum (ER) stress induced by artemisinin and its derivatives, especially in the enhancement of TRAIL‐induced apoptosis, which can be exploited for repurposing the use of artemisinins in cancer therapy.

Methods:

We show in this study a comparative profile of the ER stress induced by different derivatives of this drug, namely artemisinin, artesunate, arteether, artemether, and dihydroartemisinin, all of which are available readily and approved for treating human patients. These five derivatives were used to treat human colon carcinoma HCT116 cells and pancreatic adenocarcinoma BxPC3 cells over a range of doses.

Results:

Our data show a highly significant positive correlation between ER stress caused by these drugs and their corresponding apoptotic susceptibilities upon treatment with TRAIL.

Conclusion:

We concluded that dihydroartemisinin is the most effective contender among all the derivatives tested to enhance TRAIL‐induced apoptosis.

01 Apr 2025·JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Comprehensive metabolic profiling of Mandarin Peel different extracts obtained by conventional and green methods by Sciex LC-MS/MS-Qtrap

Author: Srivastava, Pratibha ; Gulawani, Swapnaja ; Mahajan, Sakshi ; Waghole, R. J.

Bright-attractive colored mandarin peels have bioactive phytoconstituents with health benefits but are thrown as waste that can be utilized to make useful products.Mandarin peels were extracted with water at room temperature and subsequently with hexane and methanol using the Soxhlet method.Green extraction was carried out with supercritical fluid extraction and sonication to develop comparative metabolic profiling using LC-MS/MS-QTRAP functionality using EMS-EPI with IDA methodologies.The compounds were analyzed based on their fragmentation pattern using NIST and Natural Product Library search.The most abundant flavonoid in mandarin peels was isolated, hesperidin (825 mg/ 20 g).Closely related hesperidin and rutin (610.5 g/mol), naringin and narirutin (580.5 g/mol), and naringenin were identified by developing the MRM-EPI with the IDA method and quantified hesperidin (49.18 mg.g^-1, 32 mg.g^-1), rutin (0.52 mg.g-1; 0.92 mg.g-1), naringin (0.144 mg.g^-1; 0.05 mg.g^-1), narirutin (0.29 mg.g^-1; 0.036 mg.g-1), naringenin (0.002 mg.g^-1; 0.002 mg.g-1) and trans-ferulic acid (0.117 mg.g^-1; 0.296 mg.g^-1) in Soxhlet extraction and sonication extraction method resp.The paper reports a comprehensive metabolic profiling of mandarin peel.

100 Deals associated with Arteether

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