In recent years, there has been a growing interest in the contribution of neuroretinal degeneration to the pathogenesis of diabetic retinopathy (DR).PURPOSEThis study assesses the effect of the drug Retinalamin on the functional state of the retina in patients with DR using the Diopsys NOVA Vision Testing System that utilizes electrophysiological (EP) technology.MATERIAL AND METHODSThe study included patients with type 1 and 2 diabetes mellitus (DM) with DR of any stage without macular edema. Patients underwent standard ophthalmological examination and objective functional examination of the retina using the Diopsys NOVA Vision Testing System. The control group consisted of patients with type 1 and 2 DM with DR who did not receive Retinalamin.RESULTSSignificant changes in pattern electroretinography and flash electroretinography parameters were recorded in patients who received a course of Retinalamin. Two clinical examples are presented, which can be designated as the first experience of objective functional monitoring of treatment of patients with DR with Retinalamin.CONCLUSIONRetinoprotective therapy is necessary already at the early stages of DR. Electroretinography is an objective tool for functional analysis of the earliest changes in retinal cells in DR. It is necessary to use the identified "therapeutic" window for the appointment of retinoprotective agents.

01 Jan 2021·Vestnik oftal'mologii

Effect of retinal protective therapy on optical coherence tomography angiography (pilot study)

Article

Author: Kirilik, E V ; Klimova, A V ; Solovieva, A B ; Dorofeev, D A

PURPOSETo assess the influence of the frequency of retinal protective therapy courses on the indicators of regional hemodynamics of the eye.MATERIAL AND METHODSThe study included 17 patients (34 eyes) with a diagnosis of primary open-angle glaucoma (POAG), advanced stage. The patients were divided into 2 groups: the first group received a course of retinal protective therapy with Retinalamin every 3 months, the second group received a course of retinal protective therapy with Retinalamin every 6 months. All patients underwent standard ophthalmological examination including standard automatic perimetry according to the 24-2 program, optical coherence tomography angiography (OCT-A) of the macular area and optic disc.RESULTSThe comparison of hemodynamic parameters of all vascular plexuses of the retina at the beginning and at the end of the study, as well as intergroup comparison did not reveal any statistically significant differences (p>0.05). However, when studying the density and fractal dimension of the vascular bed, multidirectional trends were observed. Specifically, in the peripapillary region, there was a decrease in the length from 19.8 (1/mm) to 19.0 (1/mm) (p=0.37) and the density from 36.6% to 35.7% (p=0.63) of the vascular bed of the peripapillary capillary plexus of the retina in patients of the first group. In the superficial vascular plexus, the trend in the density of the vascular bed in both groups slightly changed (in group 1 - 38.1% and 38.3%, p=0.97; group 2 - 37.8% and 38.7%, p=0.46). The fractal dimension of the vascular bed in the first group tended to increase during treatment from 18.8 (1/mm) to 19.1 (1/mm) (p=0.5), while in the second group, on the contrary, it had tendency to decrease from 18.6 (1/mm) to 17.9 (1/mm) (p=0.63). In the deep vascular plexus, the density of the vascular bed trended to decrease in both groups, but in group 2 (42.5% and 42.4%, p=1.0) it was more pronounced than in the first group (42.5% and 42.6%, p=0.82). However, the fractal dimension of the vascular bed increased in group 1 (21.0 (1/mm) and 21.3 (1/mm), p=0.43) and showed a slight tendency to decrease in group 2 (21.5 (1/mm) and 21.0 (1/mm), p=0.86).CONCLUSIONThe general trend of changes in hemodynamic parameters demonstrates a potential positive effect, especially in the data related to the deep vascular plexus.

01 Jan 2021·Vestnik oftal'mologii

Retinoprotective effects of Retinalamin studied in an experimental model of photochemical damage to rabbit retinas

Article

Author: Odinokaya, M A ; Alekperov, S I ; Suetov, A A ; Kostina, A A

Purpose - to investigate functional and morphological effects of peptide bioregulator (Retinalamin) in modeling of photochemical damage to rabbit retina.MATERIAL AND METHODSThe study was conducted on 36 rabbits (72 eyes) randomized into 4 equal groups: two experimental groups received parabulbar injections of Retinalamin («Geropharm», Russia) in each eye in dosages of 0.25 mg/kg in a course of 10 days starting from day 1 and day 10 of the experiment, respectively, and two control groups that received injections of normal solution with the same regimen. To simulate photochemical damage to the retina, exposure to light with a wavelength of 405 nm, a power density of 5 mW/cm² and daily exposure time of 4 h was performed for 20 days. Multifocal and flicker 30 Hz electroretinogram (mfERG and fERG) were recorded, and histological studies of retina samples with quantitative assessment of retinal cells apoptosis by the TUNEL method were conducted before, as well as 10, 20 and 30 days after the start of light exposure.RESULTSOphthalmoscopic signs of light-induced retinal degeneration were revealed 6-10 days after start of exposure in all groups. When registering mfERG and fERG in all groups, there was a significant decrease in the amplitude of N1 and P1 peaks, retinal density of the bioelectric response of the P1 component, as well as the amplitude of fERG on days 10 and 20 after the beginning of light exposure (p<0.001 in comparison with the background values), and a slight increase in the indicators on day 30. Histological examination revealed a significant decrease in the number of cells in the outer nuclear layer and an increase in the proportion of apoptotic cells in the outer and inner nuclear layers on days 10 and 20 of the experiment, with a decrease on day 30 (after cessation of light exposure). Comparison of the groups receiving Retinalamin injections from days 1 or 10 of light exposure between themselves and the control groups revealed no significant differences in any of the studied parameters (p>0.05).CONCLUSIONNo significant functional and morphological evidence of neuroprotective effects of Retinalamin were found in the model of photochemical damage to rabbit retinas.

100 Deals associated with Retinalamin

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Indication	Country/Location	Organization	Date
Diabetic Retinopathy	RU	Geropharm LLC	01 Jan 2008
Glaucoma, Open-Angle	RU	Geropharm LLC	01 Jan 2008
Retinal Dysplasia	RU	Geropharm LLC	01 Jan 2008

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