Last update 19 Jul 2025

Mesothelin and Claudin 18.2 Dual-Target CAR-T(Essen Biotech)

Overview

Basic Info

Drug Type
Autologous CAR-T
Synonyms
Autologous T-cells engineered to express CARs targeting Mesothelin and CAR-T cells(Essen Biotech), Mesothelin and Claudin 18.2 CAR-T cells(Essen Biotech)
Target
CLDN18.2 x MSLN
Action
modulators
Mechanism
CLDN18.2 modulators(Claudin 18.2 modulators), MSLN modulators(Mesothelin modulators)
Therapeutic Areas
NeoplasmsDigestive System DisordersEndocrinology and Metabolic Disease
Active Indication
Pancreatic carcinoma non-resectable
Inactive Indication-
Originator Organization
Essen Biotech
Active Organization
Essen Biotech
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with Mesothelin and Claudin 18.2 Dual-Target CAR-T(Essen Biotech)
NCT07066995
/ RecruitingPhase 1/2IIT
Dual-Target Chimeric Antigen Receptor (CAR) T-Cell Therapy Directed Against Mesothelin and Claudin 18.2 in Patients With Advanced or Metastatic Pancreatic Cancer
100 Clinical Results associated with Mesothelin and Claudin 18.2 Dual-Target CAR-T(Essen Biotech)
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100 Translational Medicine associated with Mesothelin and Claudin 18.2 Dual-Target CAR-T(Essen Biotech)
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100 Patents (Medical) associated with Mesothelin and Claudin 18.2 Dual-Target CAR-T(Essen Biotech)
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100 Deals associated with Mesothelin and Claudin 18.2 Dual-Target CAR-T(Essen Biotech)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Pancreatic carcinoma non-resectablePhase 2
China
Essen Biotech
29 Apr 2025
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Clinical Result

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Clinical Trial

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Approval

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Regulation

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