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Last update 08 May 2025

Clefamide

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Clefamide (INN)

Target-

Action-

Mechanism-

Therapeutic Areas

Infectious Diseases

Active Indication

Amebiasis

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC17H16Cl2N2O5

InChIKeyODCUSWJXZDHLKV-UHFFFAOYSA-N

CAS Registry3576-64-5

100 Clinical Results associated with Clefamide

100 Translational Medicine associated with Clefamide

100 Patents (Medical) associated with Clefamide

Literatures (Medical) associated with Clefamide

01 Oct 2015·Tetrahedron

Synthesis and solvent sorption characteristics of new types of tartaric acid, lactic acid and TADDOL derived receptor compounds

Author: Diana Eißmann ; Edwin Weber ; Felix Katzsch

The three new types of tartaric acids e.g., I, lactic acids e.g., II and TADDOL derivatives e.g., III featuring a linear shaped central backbone and terminally attached functional units corresponding to the above substance classes have been developed based on a modular design strategy.Preparation of the tartaric acid derivatives involved Pd-catalyzed cross-coupling reactions followed by transacetalization and hydrolysis of the corresponding esters in the final step of the synthetic routes.The derivatives of lactic acid have been prepared on a similar reaction sequence but with the use of lactic esters.The TADDOL derivatives were obtained by Grignard reaction between phenylmagnesium bromide and tartaric esters.Optical rotation data were specified for each compound including intermediates.Organic vapor sorption behavior of selected compounds coated as solid films on the quartz crystal of a QCM device has been studied.Significant differences in the affinities towards organic solvent vapor were observedThey both depend on structural properties of the resp. receptor solvent mols. and solvent polarity as well, showing developmental possibility in the application of vapor sensing.

12 Mar 2015·Mini-Reviews in Medicinal ChemistryQ3 · MEDICINE

Functional Correlation of Medicinal Chemistry and Entamoeba histolytica Treatment: An Emphasis on the Past, Present and Future Chemotherapy

Q3 · MEDICINE

Review

Author: Singla, Rajeev K. ; Sekaran, Shamala Devi ; Vemuri, Ravi Chandra ; Gundamaraju, Rohit

Entamoeba being an internal parasite is the causative organism of many human and animal infections with lethal consequences. Chemotherapy against Entamoeba was well established by both synthetic and natural products. Vigorous attainments were made by different researchers all over the world for discovering better chemical entities and the potent formulations. Preexisting compounds were developed into non-cytotoxic and with an enhanced therapeutic compounds by usage of multiparametric optimization techniques like QSAR, and molecular docking. The present review is therefore an aerial perspective of importance of medicinal chemistry in anti-amoebic chemotherapy. The review elucidates the existing synthetic compounds, their analogues, natural products, in silico studies and some novel methods adopted for the drug design as anti-amoebic agents which would be of assured benefit in the future drug design.

01 Dec 1984·Journal of Chromatographic Science

Application of Principal Components Analysis to TLC Data for 596 Basic and Neutral Drugs in Four Eluent Systems

Author: Sergio Clementi ; Giuseppe Scarlata ; Guido Romano ; Giuseppe Musumarra ; Svante Wold

Principal component anal. of the R_f values for 596 basic and neutral drugs in 4 eluent mixtures provided a significant 2-component model which explained 77% of the total variance.Each drug was characterized on a plane by 2 principal component scores.The loading plot shows that 3 eluent mixtures are clustered into the same group providing similar information.For identification of unknowns, the method provided a drastic reduction of the range of possibilities to a few candidates.

100 Deals associated with Clefamide

External Link

KEGG	Wiki	ATC	Drug Bank
D07354	Clefamide	P01AC02	DB13512

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Amebiasis	-	-	-

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Clefamide

Overview

Basic Info

Structure/Sequence

Related

External Link

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation