PD-DP-008

Primary Objective: To evaluate the safety and tolerability of PD-DP-008 in healthy subjects with single and multiple topical administration, and in patients with mild to moderate acne vulgaris with multiple topical administration. Secondary Objectives: To evaluate the pharmacokinetic (PK) characteristics of PD-DP-008 in healthy subjects with single and multiple topical administration, and in patients with mild to moderate acne vulgaris with multiple topical administration; to evaluate the immunogenicity of PD-DP-008 in healthy subjects with single and multiple topical administration, and in patients with mild to moderate acne vulgaris with multiple topical administration; to evaluate the preliminary efficacy of PD-DP-008 in patients with mild to moderate acne vulgaris with multiple topical administration (face only, stage Ib).