Novel series of four copper(II) complexes (I) with 2-aminobenzimidazole derivatives (obtained from the Knoevenagel condensate of acetylacetone (obtained from acetylacetone and halogen substituted benzaldehydes) and 2-aminobenzimidazole) were synthesized.They were structurally characterized using elemental anal., molar conductance, FAB mass, FT- IR, ¹H & ¹³C-NMR, UV-visible, and EPR techniques.On the basis of anal. and spectral studies, the distorted square planar geometry was assigned for all the complexes.The antibacterial screening of the ligands and their copper complexes indicated that all the complexes showed higher anti microbial activities than the free ligands.Superoxide dismutase and antioxidant activities of the copper complexes also were performed.In the electrochem. technique, the shift in ΔE_p, E_1/2 and Ipc values were explored for the interaction of the complexes with CT-DNA.During the electrolysis process, the present ligand system stabilizes unusual oxidation state of copper in the complexes.It is believed that the copper complexes with curcumin analogs may enhance chemotherapeutic behavior.

01 Apr 2017·Applied Organometallic Chemistry

Design, synthesis, characterization and biological studies of copper(II) complexes with 2‐aminobenzimidazole derivatives as biomimetic agents

Author: Suman, A. ; Balakrishnan, Nisha ; Joseph, J.

Four novel copper(II) complexes of 2‐aminobenzimidazole derivatives (obtained from the Knoevenagel condensation of acetylacetone (obtained from acetylacetone and halogen‐substituted benzaldehydes) and 2‐aminobenzimidazole) were synthesized. They were characterized using elemental analysis, molar conductance measurements, and fast atom bombardment mass, Fourier transform infrared, NMR, UV–visible and electron paramagnetic resonance spectroscopies. On the basis of the spectral studies, a distorted square planar geometry was assigned for all the complexes. The antibacterial screening of the ligands and their complexes revealed that all the complexes had higher activities than the free ligands. Superoxide dismutase and antioxidant activities of the copper complexes were also studied. The shifts in ΔEp, E1/2, Ipc and Ipa values were explored for the interaction of the complexes with calf thymus DNA using the electrochemical technique.

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