Delving into the Latest Updates on Hemoporfin with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

FMD, FuMeiDa, Hematoporphyrin monomethyl ether

+ [2]

Target-

Action-

Mechanism

Photosensitizers

Therapeutic Areas

Neoplasms

Active Indication

NevusNeoplasms

Inactive Indication-

Originator Organization

Shanghai Fudan Zhangjiang Bio Pharmaceutical Co., Ltd.

Active Organization

Shanghai Fudan Zhangjiang Bio Pharmaceutical Co., Ltd.

Taizhou Fudan Zhangjiang Pharmaceutical Co., Ltd.

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date

China (29 Sep 2016),

Neoplasms

RegulationSpecial Review Project (China)

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Structure/Sequence

Molecular FormulaC35H40N4O6

InChIKeyHWEFINLVIQZVMZ-OYYVZGGRSA-N

CAS Registry148471-91-4

ABSTRACTObjectivesSome patients with port‐wine stain (PWS) who have undergone several sessions of pulsed dye laser (PDL) treatment desire further improvement through hematoporphyrin monomethyl ether (HMME) photodynamic therapy (PDT). We attempted to analyse a possible number of recommended sessions and factors influencing the efficacy of multiple sessions of HMME‐PDT for facial PDL‐resistant PWSs.MethodsForty‐eight patients with facial PDL‐resistant PWSs who underwent at least three HMME‐PDT sessions were included in this study. All patients received an intravenous injection of HMME (5 mg/kg) followed by 532‐nm light‐emitting diode green light therapy. Cumulative improvement scores and single improvement scores were obtained after each session to evaluate the degree of improvement.ResultsThe excellent improvement rates of patients were 0% (0/48), 8.3% (4/48), 29.2% (14/48), 38.5% (10/26), and 50.0% (8/16) after 1–5 HMME‐PDT sessions, respectively. A significant difference was observed in the cumulative improvement scores (p < 0.0001). Moreover, there were significant differences between any two sessions in the first four HMME‐PDT sessions (p = 0.003). The improvement after the first HMME‐PDT session was more obvious than that after each subsequent session (p = 0.004). A PWS less than or equal to 1% of the body surface area (OR = 9.05; 95% CI, 1.42–57.57; p = 0.020) and 5–10 sessions of previous PDL treatment (OR = 8.06; 95% CI, 2.01–32.33; p = 0.003) were positive influential factors for PDL‐resistant PWS.ConclusionsWe propose that at least 4 HMME‐PDT sessions could be recommended for patients with PDL‐resistant PWSs, and the improvement after the first HMME‐PDT session was the most evident compared with that after each subsequent treatment. Moreover, greater erythema and a greater number of previous PDL session were associated with poor HMME‐PDT efficacy.

01 Apr 2025·Journal of Cosmetic Dermatology

Influential Factors in the Efficacy and Safety of Hemoporfin‐Mediated Photodynamic Therapy for Facial Port‐Wine Stains

Article

Author: Shi, Yaqian ; Yan, Hongxia ; Xiao, Rong ; You, Ruixuan ; Zhou, Yixin ; Shao, Yongqi ; Zhang, Xueqin ; Zeng, Ting ; Li, Lu ; Tan, Yixin ; Qiu, Xiangning

ABSTRACTBackgroundHemoporfin‐mediated photodynamic therapy (HMME‐PDT) is a novel and promising treatment for port‐wine stains (PWS); however, the factors affecting the efficacy and safety are controversial.AimIn this study, the relationship between influential factors and the efficacy and safety of HMME‐PDT for facial PWS was clarified.MethodsIn this retrospective study, 155 patients suffering from facial PWS who underwent HMME‐PDT at 2–3 months interval were included. The efficacy was evaluated by the facial PWS area and severity index (FSASI) scoring system based on pre‐ and post‐treatment photographs of the lesion. The demographic characteristics, lesion patterns, treatment history, number of treatment sessions, and adverse events were also recorded.ResultsAfter the first and second sessions of HMME‐PDT, 61.9% and 92.9% of patients responded, respectively. The lesion subtype, degree of lip involvement, and number of HMME‐PDT sessions were associated with the efficacy of HMME‐PDT (p = 0.014, p = 0.034, p < 0.001, and respectively). Logistic regression analysis confirmed that the patients with red‐type PWS (p = 0.019) and more HMME‐PDT sessions (≥ 2) (p < 0.001) showed an association with a better response to HMME‐PDT. The response rate was higher for lesions on the mandibular prominence area than that on the forehead area (p = 0.031). No photosensitivity or systemic adverse reactions were reported. Most adverse effects were well tolerated in all patients. Furthermore, the severity of crust was found positively associated with the efficacy (p < 0.001).ConclusionHMME‐PDT is an effective and safe treatment approach for treating facial PWS. Patients who had red‐type, nonforehead area, and more treatment sessions showed an association with better efficacy.

01 Mar 2025·JDDG: Journal der Deutschen Dermatologischen Gesellschaft

Laser and light‐based treatments for port‐wine birthmarks – a systematic review and network meta‐analysis

Review

Author: Nguyen, Lynhda ; Herberger, Katharina ; Schneider, Stefan W. ; Sorbe, Christina ; Schoen, Gerhard

SummaryPort‐wine birthmarks (PWB) are common vascular malformations in infants. Despite various laser and light‐based treatments, comparative data on their effectiveness is limited. This study compares different treatments for PWB using a systematic review and network meta‐analysis (NMA). We searched for randomized controlled trials (RCTs) and ongoing studies up to November 2023: Primary outcomes were patient satisfaction, investigator‐assessed reduction in redness, and long‐term adverse events (AEs). Risk of bias was assessed using the Cochrane Risk of Bias 2 Tool.We identified 27 RCTs for qualitative analysis and twelve RCTs for the NMA, covering 1033 observations, 19 treatments, and three sub‐networks. Seven studies reported on patient satisfaction. Hemoporfin‐mediated photodynamic therapy was more effective in lesion clearance than PDL but had the highest risk of AEs. The 755 nm alexandrite laser and the combination of 595 nm PDL + 1064 nm Nd:YAG also showed high AE risks. Treatment discontinuation rates due to AEs did not significantly differ. Most studies had unclear bias risks, mostly owing to insufficient reporting.This study is the first NMA comparing laser‐ and light‐based therapies for PWB. Further well‐designed studies are warranted to determine optimal methods and patient‐influencing factors for individualized treatments.

100 Deals associated with Hemoporfin

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