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AstraZeneca snaps up Amolyt for $1.05bn to boost rare disease pipeline
Phase 3AcquisitionPhase 1Clinical ResultPhase 2
AstraZeneca’s rare disease portfolio generated $7.76bn in global sales in 2023, as per the company’s Q4 financials. Image Credit: EllaSt / Shutterstock.
AstraZeneca has signed a definitive agreement to acquire Amolyt Pharma, which specialises in therapies for rare endocrine diseases, in a deal worth $1.05bn.
AstraZenecacontract, AstraZeneca will pay $800m upfront aAmolyt Pharmaential regulatory milestone payments of $2endocrine diseasesxpected to close in Q3 2024.
Amolyt’s lead candidaAstraZenecaratide (AZP-3601), was a central part of the acquisition. Eneboparatide is a subcutaneous parathyroid hormone receptor 1 (PTHR1) agonist for the treatment of hypoparathyroidism. This condition is caused by a deficiency in the parathyroid hormone that results in decreased calcium and elevated phosphorus levels in the blood. Dysregulation of parathyroid hormone can lead to osteoporosis and chronic kidney disease.
Amolyt launched a Phase Ieneboparatide (AZP-3601)78071) for eneboparatide in May 2023. TopEneboparatidem the trial is expeparathyroid hormone receptor 1 (PTHR1)hypoparathyroidismosteoporosischronic kidney disease
Amolytr candidate in Amolyt’s pipeline is AZP-3813. The thereneboparatideide growth hormone receptor antagonist, which is being developed as a potential add-on to somatostatin analogues for the treatment of acromegaly, a condition associated with abnormally high secretion of growth hormone. It can lead to a variety of complications including heart failure and impaired glucose tolerance. The company initiated a Phase I trial for AZP-3813 in June 2023.
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AstraZeneca’s rare disease portfolio generated $7.76bn in global sales in 2023, as per the company’s Q4 financials. The UK pharma giant has been investing heavily in rare disease therapies starting with the $39bn acquisition of Alexion in 2021. Last year, the company paid $1bn to acquire an early-stage gene therapy portfolio for rare diseases from Pfizer.
According to a GlobalData report, innovation in rare diseases is sAstraZenecaskyAZD-3427ent, with rare oncology indications dominating most of the rare disease pipeline.
GlobalData is the parent company of Pharmaceutical Technology.
AstraZenecas, AstraZeneca has seen some success amongst rare diseases that are not cancer-related. In September 2023, the Phase III trial for a rare vasculitis therapy, Fasenra (benralizumab), met its primary endpoint. The studyAlexionthat Fasenra was non-inferior to the current standard of care, Pfizer’s Nucala (mepolizumab).Pfizer
Earlier this year, AstraZeneca reported positive outcomes from its Japan Phase III clinical trial of acoramidis, an investigational treatment for a rare cardiomyopathy, transthyretin-mediated amyloid cardiomyopathy (ATTR-CM).
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