Cognitive Decline Speeds Up Following Postoperative Delirium
30 Mar 2023
THURSDAY, March 30, 2023 -- Postoperative delirium is associated with accelerated cognitive decline in older adults, according to a study published online March 20 in JAMA Internal Medicine.
Zachary J. Kunicki, Ph.D., from the Warren Alpert Medical School of Brown University in Providence, Rhode Island, and colleagues examined the patterns and pace of cognitive decline up to 72 months after major elective surgery in 560 older adults (older than 70 years).
The researchers found that 24 percent of participants developed postoperative delirium. There were differences observed in acute, post-short-term, intermediate, and longer-term cognitive change from the time of surgery that were associated with the development of postoperative delirium. When adjusting for practice and recovery effects, long-term cognitive change occurred at a pace of about −1.0 general cognitive performance (GCP) units per year. Significantly faster long-term cognitive change was seen for participants with delirium (an additional −0.4 GCP units or −1.4 units per year). Delirium was associated with a 40 percent acceleration in the slope of cognitive decline out to 72 months postoperatively.
"We cannot be sure whether delirium directly causes subsequent cognitive decline, or whether patients with preclinical brain disease are more likely to develop delirium," the authors write. "Future research is needed to understand the causal pathway between delirium and cognitive decline."
Abstract/Full Text (subscription or payment may be required)
Posted March 2023
For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Organizations
Indications
Targets
-Drugs
-Hot reports
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.