in patients with especially low kidney function
ORLANDO, Fla. and YONGIN, South Korea, Nov. 4, 2022 /PRNewswire/ -- Aptabio will present Isuzinaxib Phase 2 clinical trial[1] results at the American Society of Nephrology (ASN)'s Kidney Week 2022 in Orlando, FL. The study results will be presented in High-Impact Clinical Trials, oral abstract session.
Friday, November 4, 10:30 a.m. – 12:30 p.m. EDT Oral Abstract Session
Isuzinaxib (APX-115) is a novel investigational pan-NOX inhibitor modulating to oxidative stress that leads a critical pathogenic factor in the initiation and progression of diabetic complications. The results of a randomized, double-blind, placebo-controlled phase 2 study in 140 patients with diabetes and chronic kidney disease showed that Isuzinaxib was effective on major kidney function markers (Urine Albumin Creatine Ratio and Kidney Injury Molecule-1), especially the patients with a low kidney function (CKD Grade 3b) achieved an UACR difference -47% in the Isuzinaxib group in 12-week treatment orally compared to the placebo group. The NADPH-oxidase (NOX) enzymes represent a family of seven membrane enzymes, which catalyze NADPH-dependent generation of superoxide and secondary Reactive Oxygen Species (ROS) which can cause tissue damage and modification of cell function. NOXs-mediated ROS production triggers for increased oxidative metabolism leading to inflammatory responses and profibrotic factors. Targeting NOX enzymes may lead to more effective inhibition of oxidative stress at early stage of ROS production. ROS triggers kidney cells to secret cytokines which potentiate activation of macrophages, that also contribute to Diabetic Kidney Disease. Platform Technology-Based First-in-Class New Drug Development Company
Aptabio is a Korean biopharmaceutical company established in 2009. Since then, Aptabio has thrived by being a pioneer and an innovator in the biopharmaceutical industry, developing platform-based first-in-class drugs for intractable diseases. The word 'Apta' means 'too fit' in Greek. To fit the unmet needs of the patients with the intractable disease, Aptabio pursues scientific excellence in developing new drugs hoping to provide a better cure and life for such patients and their families. Find more information at http://www.aptabio.com/
Hyesung Shin, [email protected]