Bio-Thera Solutions Announces BAT8006 (Folate-Receptor-α-ADC) and BAT8008(Trop2-ADC) Poster Presentations at the 2022 San Antonio Breast Cancer Symposium

05 Dec 2022
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Phase 1ADCClinical Result
GUANGZHOU, China--(BUSINESS WIRE)-- Bio-Thera Solutions, a commercial-stage biopharmaceutical company developing a pipeline of innovative therapies and a pipeline of biosimilars, today announced the company will present two posters at the 2022 San Antonio Breast Cancer Symposium (SABCS) taking place December 6 - 10, 2022 in San Antonio, Texas. The first poster, entitled “BAT8006, a novel FRα-ADC with strong bystander effect, for the treatment of advanced solid tumor,” will present preclinical data and initial phase 1 clinical data that highlight advantages demonstrated by BAT8006 as a potential treatment for patients with solid tumors, such as ovarian cancer and breast cancer. An abstract of the presentation is currently available on the SABCS website. Presentation details are as follows: Poster Session: Session Date and Time: Thursday, December 8, 7:00 am – 8:15 am Location: Poster Area/Exhibition Hall Poster Board Number: P4-01-12 The second poster, entitled “BAT8008, a novel Trop-2 ADC with strong bystander effect, for the treatment of Trop-2 positive cancer,” will present preclinical data that highlight advantages demonstrated by BAT8008 as a potential treatment for Trop-2 positive cancerpatients. An abstract of the presentation is currently available on the SABCS website. Presentation details are as follows: Poster Session: Session Date and Time: Thursday, December 8, 7:00 am – 8:15 am Location: Poster Area/Exhibition Hall Poster Board Number: P4-01-32 BAT8006 and BAT8008 are two new ADC assets being developed with Bio-Thera’s next-gen ADC platform that utilizes a systemically stable cleavable linker, a potent Topoisomerase 1 inhibitor (Exatecan) as the payload, and high DARs that takes advantage of the bystander effect to increase efficacy. Other new ADC assets developed using this next-gen ADC platform include BAT8007 (Nectin4-ADC), BAT8009 (B7-H3-ADC) and BAT8010 (Her2-ADC). All of these ADC assets are currently in, or about to begin, Phase 1 clinical trials. About BAT8006 BAT8006 is an investigational Folate Receptor-alpha-ADC being evaluated in multiple tumor types. Folate Receptor is a naturally occurring receptor that is overexpressed in many types of cancer, including breast cancer and ovarian cancer. BAT8006 is being developed for use as a single agent and in combination with other agents for the treatment of multiple cancers. BAT8006 is currently being evaluated in a Phase 1 clinical trial evaluating the pharmacodynamics and safety of BAT8006 (more information on the Phase 1 clinical trial is available at https://clinicaltrials.gov/ct2/show/NCT05378737). About BAT8008 BAT8008 is an investigational Trop-2-ADC being evaluated in multiple tumor types. Trop-2 is a naturally occurring receptor that is overexpressed in many types of cancer, including triple negative breast cancer and gastric cancer. BAT8008 is being developed for use as a single agent and in combination with other agents for the treatment of multiple cancers. BAT8008 is currently being evaluated in a Phase 1 clinical trial evaluating the pharmacodynamics and safety of BAT8008 (more information on the Phase 1 clinical trial is available at https://clinicaltrials.gov/ct2/show/NCT05620017). About Bio-Thera Solutions Bio-Thera Solutions, Ltd., a leading global biotechnology company in Guangzhou, China, is dedicated to researching and developing novel therapeutics for the treatment of cancer, autoimmune, cardiovascular diseases, and other serious unmet medical needs, as well as biosimilars for existing, branded biologics to treat a range of cancer and autoimmune diseases. A leader in next generation antibody discovery and engineering, the company has advanced six candidates into late-stage clinical trials and has two approved products, QLETLI® and POBEVCY® in China. In addition, the company has multiple promising candidates in early clinical trials and IND-enabling studies, focusing on immuno-oncology, ADC targeted therapies, autoimmune diseases, and other severe and emerging unmet medical needs. For more information, please visit www.bio-thera.com/en/ or follow us on Twitter (@bio_thera_sol) and WeChat (Bio-Thera).
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