Pantoprazole Cuts GI Bleeding in Patients Undergoing Invasive Ventilation
17 Jun 2024
Clinical Result
MONDAY, June 17, 2024 -- Pantoprazole results in a significantly lower risk for clinically important upper gastrointestinal bleeding than placebo, with no increase in mortality, among patients undergoing invasive ventilation, according to a study published online June 14 in the New England Journal of Medicine to coincide with the annual Critical Care Reviews Meeting, held from June 12 to 14 in Belfast, Northern Ireland.
Deborah Cook, M.D., from McMaster University in Hamilton, Ontario, Canada, and colleagues assigned critically ill adults who were undergoing invasive ventilation to receive intravenous pantoprazole (40 mg daily) or matching placebo in an international randomized trial. Overall, 4,821 patients in 68 intensive care units were randomly assigned.
The researchers found that clinically important upper gastrointestinal bleeding occurred in 25 of 2,385 and 84 of 2,377 patients receiving pantoprazole and placebo, respectively (1.0 versus 3.5 percent; hazard ratio, 0.30; 95 percent confidence interval, 0.19 to 0.47; P
"The use of pantoprazole resulted in a lower risk of clinically important upper gastrointestinal bleeding than the use of placebo, with no overall effect on mortality," the authors write.
Abstract/Full Text (subscription or payment may be required)
Editorial (subscription or payment may be required)
More Information
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.
For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Organizations
Indications
Targets
-Hot reports
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.