According to the latest interim results, at a median follow-up of 9.7 months, the median duration of response (mDOR) in the overall study population was 11.8 months, while 49.6% of responders remained in response at one year. In patients with IHC 2+ expression, the ORR was 27.2%, rising to 61.3% in those with IHC 3+ expression. Meanwhile, the mDOR in these two groups was 9.8 months and 22.1 months, respectively.
Lead author Funda Meric-Bernstam said "these results advance our clinical understanding of HER2 expression, reaffirm HER2 as an actionable biomarker across a broad range of tumour types, and show that [Enhertu] could potentially provide a new treatment option for patients with advanced disease across these tumours, especially in patients with HER2 IHC 3+ or 2+ expression."
The highest responses by tumour type in DESTINY-PanTumor02 were seen for endometrial cancer and cervical cancer, where the ORR in those with IHC 3+ expression was 84.6% and 75%, respectively. Results showed that while the majority of patients were able to tolerate Enhertu, with the most common treatment-related side effects being nausea, fatigue and cytopenia, 11.6% of participants stopped treatment due to adverse events (AEs). Grade ≥3 AEs occurred in 58.4% of patients, with drug-related interstitial lung disease/pneumonitis occurring in 7.5% of study subjects, although the majority were low grade.
Commenting on the findings, ASCO expert Bradley Alexander McGregor noted "while additional follow-up is needed, there is robust activity across multiple HER2expressing tumours with over 50% response rate in those with the highest levels of HER2 expression coupled with an encouraging safety profile."
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