Mesenchymal Stem Cell-Neural Progenitors Beneficial for MS
13 Jun 2024
Clinical ResultCell TherapyClinical Study
THURSDAY, June 13, 2024 -- Select patients with progressive multiple sclerosis (MS) may benefit from mesenchymal stem cell-neural progenitors (MSC-NPs), according to a study published online May 23 in Stem Cell Research & Therapy.
Violaine K. Harris, Ph.D., from the Tisch Multiple Sclerosis Research Center of New YorkMultiple Sclerosis Research Center of New York in New York City, and colleagues conducted a randomized, double-blind trial with a compassionate crossover design at a single site. Participants were stratified according to the baseline Expanded Disability Status Scale (EDSS, 3.0 to 6.5) and disease subtype (secondary or primary progressive MS) and were randomly allocated to treatment (six intrathecal [IT] injections of autologous MSC-NPs) or placebo (saline) every two months (27 in each group).
The researchers found no differences between the MSC-NP and saline groups in the EDSS Plus, defined by improvement in EDSS, timed 25-foot walk (T25FW), or nine-hole peg test (33 and 37 percent, respectively). A significantly higher percentage of improvement in the T25FW and six-minute walk test was seen in the MSC-NP group than the saline group in an exploratory subgroup analysis involving participants who required assistance for ambulation (EDSS, 6.0 to 6.5). Improved bladder function and reduced rate of grey matter atrophy on brain magnetic resonance imaging was also seen with IT MSC-NP treatment. Following treatment, there were increased MMP9 and decreased CCL2 levels in the cerebrospinal fluid.
"Our study provides multiple lines of clinical and laboratory evidence that demonstrate efficacy of IT MSC-NP therapy in progressive MS," the authors write. "Future studies employing ambulatory measures as primary end points and investigating optimal dosing of MSC-NPs are needed."
Two authors are inventors on a U.S. patent.
Abstract/Full Text
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.
For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Indications
Drugs
Hot reports
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.