TransThera initiates IND-Enabling studies for TT-02332, a novel, highly potent and CNS-penetrating NLRP3 inhibitorNLRP3 inhibitor
26 Feb 2024
NANJING, China and GAITHURSBURG, Md., Feb. 26, 2024 /PRNewswire/ -- TransThera, a clinical-stage biopharmaceutical company dedicated to innovating differentiated drugs globally, today announced the initiation of IND-enabling studies for TT-02332, a potent, selective and highly CNS-penetrating NLRP3 inflammasome inhibitorNLRP3 inflammasome inhibitor. The NLRP3 inflammasome is a pivotal component of the human innate immune system. Aberrant activation of NLRP3 is strongly linked with a variety of inflammatory disorders, including obesity, neurodegenerative diseases, NASH, inflammatory bowel disease (IBD), dermatitis, and atherosclerosis.
"Immuno-inflammation is one of TransThera's key therapeutic areas of interest. Over the past three years, we have achieved breakthroughs with the NLRP3 inhibitorNLRP3 inhibitor program." said Jennifer Sheng, Vice President of Biology at TransThera. "Our clinical candidate compound TT-02332 is a highly potent NLRP3 inhibitorNLRP3 inhibitor that has shown promising efficacy in a number of disease-relevant in vivo animal models. The compound exhibits desirable pharmacokinetic/ pharmacodynamic (PK/PD) properties, suitable for once-daily dosing. TT-02332 demonstrates an excellent safety profile in recently completed repeated-dose toxicity studies in two animal species (Dose finding toxicity studies). Based on these encouraging preclinical data, we are excited to advance IND-enabling studies of TT-02332."
Because NLRP3 inhibition has therapeutic potential in a broad range of inflammatory disorders, TransThera has built a holistic portfolio on this target. TT-02332 is a clinical candidate compound with high brain penetration and has great therapeutic potential in neurodegenerative diseases, reversal of obesity and related cardiovascular risks. In addition, the company is developing a series of low CNS exposure NLRP3 inhibitorsNLRP3 inhibitors for the treatment of periphery inflammatory diseases, including NASH, dermatitis and IBD, with the candidate compound to be selected in the coming months. The initiation of IND-enabling studies of TT-02332 represents an important step forward in TransThera's efforts to bring potentially transformative therapeutics to patients more quickly.
About TransThera
TransThera, including TransThera Sciences (Nanjing), Inc. and TransThera Sciences (US) Inc., is a clinical-stage biopharmaceutical company dedicated to developing innovative therapeutics to target diseases with major unmet medical needs via the internal research platform and open innovation. TransThera's current portfolio covers therapeutic areas such as oncology, inflammatory, and cardiovascular diseases.
For more information, please visit www.transthera.com
Forward-looking statements
This news contains forward-looking statements that involve risks, uncertainties, and assumptions. If risks or uncertainties ever materialize or the assumptions prove incorrect, our actual results may differ from those expressed or implied by such forward-looking statements. All statements other than statements of historical facts could be deemed forward-looking, including, but not limited to, any statement of the plans, strategies, and objectives of management for future operations, including but not limited to our clinical development and commercialization plans; any projections of financial information; any statements about historical results that may suggest trends for our business; any statements of expectation or belief regarding future events, potential markets or market size, technology developments, our product pipeline, clinical data, results or practices or the implications thereof, enforceability of our intellectual property rights, competitive strengths or our position within the industry; and any statements of assumptions underlying any of the items mentioned.
SOURCE TransThera Sciences (Nanjing) Inc.
For more details,please visit the original website
The content of the article does not represent any opinions of Synapse and its affiliated companies. If there is any copyright infringement or error, please contact us, and we will deal with it within 24 hours.
Organizations
Indications
Targets
Drugs
Hot reports
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Leverages most recent intelligence information, enabling fullest potential.