Sichuan Province Yangguangrunhe Pharmaceutical Co. Ltd.

A multicenter, randomized, double-blind, double-dummy, parallel, positive-controlled method was used to evaluate the efficacy and safety of morphine sulfate and naltrexone hydrochloride sustained-release capsules in patients with moderate to severe cancer pain.

Primary objective: To evaluate the pharmacokinetic (PK) interaction of utagliptin tablets and metformin hydrochloride tablets in healthy subjects. Secondary objective: To evaluate the safety and tolerability of utagliptin tablets and metformin hydrochloride tablets in healthy subjects.

Primary objective: To compare the pharmacokinetic characteristics of naltrexone and its metabolite 6-β-naltrexol in patients with mild to moderate chronic pain using crushed morphine sulfate naltrexone hydrochloride sustained-release capsules (Chengdu Yuandong Biopharmaceutical Co., Ltd.) and naltrexone hydrochloride solution.