A randomized, double-blind, double-dummy crossover study on 42 asthmatics was carried out to compare the single dose effects of salbutamol administered from the widely used metered dose inhaler and a breath operated system (Diskhaler®). The bronchodilator response (change in forced expiratory volume in the first second) was almost identical for the two systems. The Diskhaler® system however, since it is breath operated, obviates the need for hand–breath coordination.

01 Jun 1985·British Journal of Clinical PharmacologyQ2 · MEDICINE

Effect of ranitidine on procainamide disposition [letter]

Q2 · MEDICINE

Letter

Author: Martin, B. K.

A polemic.The suggestion that ranitidine [66357-35-5] impairs the absorption of procainamide [51-06-9] as forwarded by A. Somogyi and F. Bochner (ibid, 1984, 18, 175-81) may not be correct.This observation was based upon the decreased renal clearance of procainamide and its major metabolite N-acetylprocainamide in the presence of ranitidine and the changes in the ratio of hepatic clearance and bioavailability of procainamide.However, decreased renal clearance of the drug and major metabolite may lead into elimination of other metabolites and thus may not be the consequence of impaired absorption.

Acta Therapeutica

Comparative bioavailability of erythromycin from enteric-coated pellets of erythromycin base and a suspension of erythromycin ethyl succinate

Author: Hayden, J. ; Halsall, G. M. ; Thomas, A. M. ; Martin, B. K. ; Rogers, M. S. ; Clarke, L.

Plasma levels of erythromycin from 3 treatments were compared in an open, single dose, 3-way cross-over study in 12 volunteers.The treatments were enteric-coated pellets of erythromycin base (500 mg) sprinkled on yogurt or jam, or erythromycin ethyl succinate suspension (1 g).Plasma samples were collected immediately prior to dosing and after 1-9 h.Samples following erythromycin ester dosage were assayed for total erythromycin and erythromycin ester, the concentration of erythromycin base then being calculated by difference.The erythromycin base formulation displayed very similar plasma concentration vs. time curves when administered on either yogurt or jam.However, total erythromycin levels from the ethyl succinate formulation were significantly lower than those produced by the base formulation and less than half of the erythromycin was present as the active base.There were no adverse experiences reported on any of the treatments.

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