Delving into the Latest Updates on Sanford Medical Center with Synapse

Overview

The SATURN trial aims to determine whether continuation vs. discontinuation of statin drugs after spontaneous lobar intracerebral hemorrhage (ICH) is the best strategy; and whether the decision to continue/discontinue statins should be influenced by an individual's Apolipoprotein-E (APOE) genotype.
An MRI ancillary study (SATURN MRI), in a subset of SATURN participants , will evaluate the effects of continuation vs. discontinuation of statin drugs on hemorrhagic and ischemic MRI markers of cerebral small vessel disease, and whether the presence/burden of hemorrhagic markers (i.e. cerebral microbleeds and/or cortical superficial siderosis) on baseline MRI influences the risk of ICH recurrence on/off statin therapy.

Start Date10 Jun 2020

Sponsor / Collaborator

Beth Israel Deaconess Medical Center, Inc.

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100 Clinical Results associated with Sanford Medical Center

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0 Patents (Medical) associated with Sanford Medical Center

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88

Literatures (Medical) associated with Sanford Medical Center

01 Jun 2025·The Journal of Pediatrics

The Interaction of Antenatal Steroid Timing and Pre-Eclampsia on Respiratory Outcomes Among Infants Born Preterm

Article

Author: Tan, April W ; Schmidt, Augusto F ; Hamza, Mohamed ; Bancalari, Eduardo ; Claure, Nelson ; Aguilar, Ana Cecilia ; James, Chanique ; Schott, Alini

OBJECTIVETo evaluate the effect of timing of antenatal steroid (ANS) administration and its interaction with pre-eclampsia on respiratory outcome among infants born preterm.STUDY DESIGNThis was an analysis of a prospective, single-center cohort of infants born between 23 and 30 weeks of gestation between 2012 through 2021. End points were severe respiratory distress syndrome (sRDS) and moderate-to-severe bronchopulmonary dysplasia (msBPD). ANS administration was classified as within 7 days of birth or earlier than 7 days before birth. Multivariable generalized estimating equations were used to model the association between ANS timing and pre-eclampsia with the end points.RESULTSThe cohort included 1172 infants, of whom 30% were born to mothers with pre-eclampsia and 83% to mothers who received ANS within 7 days of birth. Compared with non-pre-eclampsia with ANS within 7 days of birth, pre-eclampsia with ANS earlier than 7 days before birth was associated with an increased risk for sRDS. Pre-eclampsia with ANS within 7 days of birth was not associated with an increased risk for sRDS. Compared with non-pre-eclampsia with ANS within 7 days of birth, non-pre-eclampsia with ANS earlier than 7 days of birth, and pre-eclampsia with ANS earlier than 7 days before birth were associated with an increased risk for msBPD. Pre-eclampsia with ANS within 7 days of birth was not associated with increased risk of msBPD.CONCLUSIONSIn this cohort, properly timed maternal ANS administration within 7 days of birth was associated with a reduced risk of sRDS and msBPD among infants born preterm to mothers with pre-eclampsia. These findings underscore the need to optimize the timing of ANS administration.

12 Nov 2024·Circulation

Abstract 4147143: The value of high coronary artery calcium score (CACS) in prediction of stroke incidence.

Author: Bartaria, Shubhi ; Maryniak, Andrii ; Petrasko, Marian ; Oleszak, Filip ; Stys, Tom ; Hajek, Catherine ; Pham, Melissa ; GU, SHAOPENG ; Rajpurohit, Naveen ; Larson, Eric ; Stys, Adam ; Rotter, Jerome ; Wasef, Natale ; Guo, Xiuqing

Introduction: In multiple recent studies, a higher coronary artery calcium score (CACS) has been associated with a higher risk of MACE and all-cause mortality. The relationship between coronary artery calcium (CAC) and the incidence of stroke is poorly defined.Method: Patients were obtained from the Sanford heart screening program from April 25, 2011 through June 23, 2023. The sample was limited to only those who underwent a CACS. A high CACS was deemed as anything greater than or equal to 300, whereas anything lower was identified as non-high CACS. The odds ratio was calculated via multiple logistic regression to analyze the data.Results: A total of 33249 patients with CACS were analyzed in this study. The average age of the patients is 56.19 (SD =9.97) and 46% of them are male. Among all the patients in the study, 3529 had a high CACS, of which 399 of them had stroke (11.3%). Our study shows that there is a positive effect between a high CACS and the incidence of stroke. The odds of having stroke are predicted to be 1.95 times larger in patients with high CACS (P-value < 0.001). In comparison to the patients who smoke frequently, the odds of developing a stroke shrink by a factor of about 0.53 and 0.48 for patients who do not smoke (P-value < 0.001) and patients who smoke occasionally (P-value=0.003), respectively. Furthermore, a five-year increase in age results in a 32% increase in odds of developing a stroke for patients with CACS less than 300 (P-value < 0.001), and a 17% increase in odds of developing a stroke for patients with high CACS (P-value = 0.006). However, for each additional year after CACS testing, the odds of stroke decreased by 18%, for patients with CACS less than 300 (P-value < 0.001), and 27%, for patients with high CACS (P-value < 0.001), likely due to interventions done.Conclusion: Our study showed that a high coronary artery calcium score predicts an increased incidence of stroke in our patient population.

01 Oct 2024·American Journal of Gastroenterology

S2707 Emergence of Postoperative Pancreatitis: Unveiling the Rare Consequence of Non-Abdominal Surgery

Author: Bassett, John ; Khan, Hasrat ; Sriramoju, Anil ; Sidhu, Guneet

100 Deals associated with Sanford Medical Center

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100 Translational Medicine associated with Sanford Medical Center

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