Author: Yadav, Vishnu Prasad ; Verma, Garima ; Mishra, Manoj Kumar ; Yadav, Vimal Kumar ; Shukla, Ajay Kumar ; Sharma, Maya ; Tiwari, Aarti ; Kanaujia, Kunal Agam

ABSTRACT: The study evaluated the preliminary phytochemical properties, isolation, characterization, antioxidant, and antimicrobial activities of the methanol extract of Achyranthes aspera Linn. The plant material was collected, extracted, and subjected to thin-layer chromatography and preliminary phytochemical analysis. The antioxidant and antibacterial properties of AAME were assessed using in-vitro techniques, including the 2,2-diphenyl-1-picrylhydrazyl assay and the agar gel plate method. Bioactive compounds were separated and characterized using Fourier-transform infrared spectroscopy. The Rf values were obtained 0.74, 0.68, 0.19, 0.20, 0.24, 0.36, 0.44 and 0.64, these Rf values data reference sources indicated that these bioactive compounds are present in extract such as ferulic acid, caffeic acid, oleanolic acid, ursolic acid, Flavonoid-VII, Phenolic acid-VI, Flavonoid-III, and Flavonoid-I. After the Rf values confirmation were isolated a compound through the TLC method that was found to be derivatives of quercetin (Flavonoid-III). Isolated compound was confirmation using FTIR interpretation results. Additionally, the presence of the results demonstrated that AAME exhibited significant antioxidant activity, comparable to standard ascorbic acid. Moreover, its antibacterial activity against infection-causing bacterial strains was found to be comparable to that of a standard drug. These findings suggested that AAME, in its entirety, possesses potent antioxidant properties and could serve as a valuable natural source of antibacterial and antioxidant agents for topical applications.

05 Feb 2025·Industrial & Engineering Chemistry Research

Conformational Stability of α-Lactalbumin and Lysozyme in Ammonium-Based Ionic Liquids: A Comprehensive Insight into Structure–Activity Relationship

Author: Singh, Poonam ; Dey, Nilanjan ; Singh, Dharmendra ; Patra, Swapan

This work studies the conformational stability of α-lactalbumin (α-LA) and lysozyme (Lys) in the presence of ammonium-based ionic liquids (ILs), such as N-butyl-pyridinium bromide ([BPy][Br]) and 1-butyl-3-methylimidazolium bromide ([Bmim][Br]) with varying aromatic residues.The spectroscopic studies indicated that [BPy][Br] could bind strongly with α-LA and induced conversion of α-helix to more β-sheet like structure via H-bonding, charge-pairing, and π-stacking interactions with aromatic amino acid residues (also verified by mol. docking studies).Moreover, the effects of pH, temperature, concentration and presence of ionic electrolytes on binding isotherm were studied.Unlike α-LA, Lys appeared to be more resistant to IL-induced interactions, maintaining its 3D-structure and optical properties over a wider IL concentration range.These differences stem from alterations in protein surface charge, secondary structure, and IL-protein interactions, particularly the ability of ILs to disrupt hydrogen bonding and hydrophobic interactions.[Bmim][Br] despite of its better mobility and ion transport property showed poor interaction with α-LA as compared to [BPy][Br].This could possibly be due to larger hydrophobicity and superior π-stacking ability of pyridinium rings than that of imidazolium units with amino acid residues.These findings provide insights into protein-IL interactions, with implications for protein engineering, biocatalysis, and biopharmaceutical formulation.

22 Jan 2025·Advances in Psychology, Mental Health, and Behavioral Studies

Managing Ethical and Regulatory Challenges in Insights From IoB Applications

Author: Shukla, Arunima ; Kumar, Deepak ; Attwal, Kanwal Preet Singh ; Gupta, Deepak ; Suryavanshi, Ajay ; Chaudhary, Arun Kumar ; Singh, Warshi ; Agarwal, Deepak

Internet of Behavior (IoB) is a powerful technology that uses human related insight as an data to monitor, evaluate and even alter behavior through connected devices & appended applications. But the rising IoB wave comes with heavy ethical and regulatory hurdles, especially in relation to data privacy, security, informed consent and algorithmic bias. This chapter looks at challenges of navigating these questions, arguing for a rigorous structure in place that helps maintain ethical guidelines of behaviorial data usage. Facebook-Cambridge Analytica scandal and Fitbit health data privacy are real-world case studies offer indications of just how bad things could get with almost zero protections in place that will ensure particular IoB technology is as safe. Global legislations and ethical AI frameworks like GDPR, HIPAA, CCPA are necessary for any organization to abide by legions of regulations. Chapter concludes with an exploration of stakeholder theory and risk management, as well regulatory measures designed to ensure compliance by companies like part of which it includes consequences

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