Request Demo

Last update 08 May 2025

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

Education|1958|Russia|

web.nioch.nsc.ru

Education|1958|Russia|

web.nioch.nsc.ru

Last update 08 May 2025

Overview

Pipeline

Deal

Translational Medicine

Overview

100 Clinical Results associated with N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

0 Patents (Medical) associated with N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

338

Literatures (Medical) associated with N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

01 Apr 2025·Bioorganic Chemistry

Synthesis and physicochemical properties of new phosphoramide oligodeoxyribonucleotides. I. N-caffeine derivatives

Article

Author: Novgorodtseva, Alina I ; Lomzov, Alexander A ; Vorob'ev, Aleksey Y ; Vasilyeva, Svetlana V

Herein, we report the synthesis of new oligonucleotide derivatives containing an internucleotide N-caffeine phosphoramide (PN-caffeine) group. This modification was introduced via Staudinger's reaction with an appropriate caffeine azide during standard solid-phase oligonucleotide synthesis. Modified hexathymidylates and oligonucleotides with a heteronucleotide sequence were obtained with a yield of ∼90 %. Physicochemical properties of the new oligonucleotides were analyzed next. UV spectral determination of pK_a showed that the PN-caffeine group is neutral at pH < 5 and is negatively charged at pH > 8. The modified oligonucleotides emit weak fluorescence, and the same is true for different charge states of the PN-caffeine moiety and its positions in the DNA strand. A decrease in melting temperature of DNA/DNA and DNA/RNA duplexes was observed after the modification introduction into the DNA. Circular dichroism analysis indicated that the modification does not significantly disrupt either a DNA/DNA or DNA/RNA duplex at either low or high temperatures. This modification expands the existing classes of phosphoramide derivatives of nucleic acids and can be used for various biomedical applications.

01 Jan 2025·Mendeleev Communications

New thiosemicarbazones possessing activity against SARS-CoV-2 and H1N1 influenza viruses

Author: Zhupikova, Olga A. ; Fedorov, Alexey Yu. ; Belenkaya, Svetlana V. ; Pyankov, Oleg V. ; Mikhalsky, Mikhail G. ; Shcherbakov, Dmitriy N. ; Potkin, Vladimir Ivanovich ; Arkhipov, Sergey G. ; Khvostov, Mikhail V. ; Meshkova, Yulia V. ; Zaykovskaya, Anna V. ; Yarovaya, Olga Ivanovna ; Marenina, Mariya K. ; Salakhutdinov, Nariman Faridovich ; Zarubaev, Vladimir V. ; Ivanov, Andrey Viktorovich ; Kolesnik, Irina A.

New thiosemicarbazones based on 5-arylisoxazole-3-carbaldehyde and substituted pyrrolecarbaldehydes have been obtained. The test for ability to inhibit the main viral protease 3Clpro of SARS-CoV-2 virus revealed a compound with activity against both corona- and influenza viruses.

01 Jan 2025·Mendeleev Communications

Synthesis of perfluorobiphenyl tetracarboxylic acids via the CuCl2-assisted homocoupling of organozinc reagents

Author: Komarov, Vladislav V ; Vinogradov, Andrey Sergeevich ; Mezhenkova, Tatyana Vladimirovna ; Platonov, Vyacheslav Evdokimovich

New organozinc reagents were obtained from ethyl esters of tetrafluorophenylene dicarboxylic acids in the reaction with Zn and SnCl2 in DMF. Tetraethyl perfluorobiphenyl tetracarboxylates were synthesized from these organozinc reagents under the action of CuCl2 and then were hydrolyzed into perfluorobiphenyl tetracarboxylic acids.

100 Deals associated with N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

100 Translational Medicine associated with N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

Corporation Tree

Boost your research with our corporation tree data.

view full example data

Pipeline

Pipeline Snapshot as of 19 Sep 2025

No data posted

Deal

Boost your decision using our deal data.

view full example data

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Profit

Explore the financial positions of over 360K organizations with Synapse.

view full example data

Grant & Funding(NIH)

Access more than 2 million grant and funding information to elevate your research journey.

view full example data

Investment

Gain insights on the latest company investments from start-ups to established corporations.

view full example data

Financing

Unearth financing trends to validate and advance investment opportunities.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry

Overview

Related

Corporation Tree

Pipeline

Pipeline Snapshot as of 19 Sep 2025

Deal

Translational Medicine

Profit

Grant & Funding(NIH)

Investment

Financing