Dermatology Partners, Inc.

This trial evaluated the effectiveness and safety of Bellafill for full-face acne scar treatment.

In this open-label, nonrandomized, multicenter pilot study investigating the use of polymethylmethacrylate for full-face atrophic acne scar correction, 42 adult subjects with a mean age of 43 years were treated and assessed for safety and effectiveness at Months 4 and 7. There were no hypersensitivity reactions to pretreatment skin testing or during scar treatments.

At 4 and 7 months after initial treatment, 92% and 95% of subjects, respectively, were responders with ≥1-point improvement on the 5-point Acne Scar Assessment Scale. Subjects reported very high levels of improvement on the Global Aesthetic Improvement Scale (GAIS), with 95% of subjects reporting “improved or better” at 4 months and 90% at 7 months. The outcome of the physician GAIS was also high with 92% of patients classified as “improved or better” at 4 months and 97% at 7 months. There were only 2 device-related adverse events, both mild events related to Bellafill skin test (bruising, ecchymosis). There were no serious adverse events in response to the treatment product in this short-term follow-up study.

Polymethylmethacrylate is effective for treating full-face acne scarring. Clinicaltrials.gov #NCT02642627.

A review.Facial rejuvenation should focus on reversing the aging process by addressing skin texture, tone, and tightness.Dermatologists accomplish this by addressing skin laxity, deep folds, and dyschromia that combine to create an aged or dulled appearance.Cosmeceuticals act as adjuvants to the armory of effective in-office procedures (e.g., injectables and toxins, lasers treating pigment and vascular aberrations, intense pulsed light, ablative resurfacing, and chem. peels) with low risk of side effects while enhancing the efficacy of these sometimes costly and painful procedures.There are a number of nonprescription but scientifically studied agents that focus specifically on skin texture, pigmentary changes, and elasticity, which will be reviewed here.