PURPOSE OF REVIEWThis review aims to highlight the evolution and multifaceted benefits of modern sulfonylureas (SUs) in managing Type 2 Diabetes Mellitus (T2DM). It discusses their enhanced glycemic control, pleiotropic advantages, usage with other antidiabetic agents, safety, and tolerability, supporting their persistent relevance and effectiveness in diabetes care.RECENT FINDINGSRecent findings indicate that modern SUs, like glimepiride, offer significant cardioprotective and renoprotective benefits along with their primary role in glycemic control. Additionally, they have also shown their anti-inflammatory effects, lipid-lowering properties, testosterone-enhancing effects, and neuroprotective effects in recent years. These findings support the broader therapeutic advantages of modern SUs beyond glucose lowering. Hence, many guidelines now recommend modern SUs as an add-on therapy to metformin. Modern sulfonylureas remain a vital component in T2DM management strategy due to their efficacy, safety profile, and cost-effectiveness. Their pleiotropic benefits, like cardiovascular, renal, anti-inflammatory, neuroprotective effects, etc., make them a comprehensive therapeutic option. Considering their efficacy and safety profile, SUs are expected to remain vital components of antidiabetic therapy, providing valuable benefits in managing T2DM in the long run.

01 Dec 2024·Endocrine Practice

Neuropsychiatric Effects of Tirzepatide: A Systematic Review and Meta-Analysis

Article

Author: Kamrul-Hasan, A B M ; Nagendra, Lakshmi ; Shrestha, Dina ; Pappachan, Joseph M ; Dutta, Deep ; Borozan, Sanja

01 Mar 2024·Indian Journal of Endocrinology and Metabolism

Global Warming and Endocrinology: The Hyderabad Declaration of the South Asian Federation of Endocrine Societies

Article

Author: Sahay, Rakesh ; Latheef, Ali ; Raza, Syed Abbas ; Kalra, Sanjay ; Murad, Moosa ; Maskey, Robin ; Bhattacharya, Saptarshi ; Nagendra, Lakshmi ; Shrestha, Dina ; Somasundaram, Noel ; Selim, Shahjada ; Muthukuda, Dimuthu ; Sheikh, Aisha ; Anne, Beatrice ; Harikumar, K. V. S. ; Parajuli, Naresh ; Baheer, Mohammed Daud ; Afsana, Faria ; Aamir, Azizul Hasan ; Ramakrishnan, Santosh ; Kamrul-Hasan, A. B. M. ; Mondal, Sunetra ; Naseri, Mohammad Wali ; Widanage, Niranjala Meegoda

AbstractGlobal warming and endocrine disorders are intertwined issues posing significant challenges. Greenhouse gases emanating from human activities drive global warming, leading to temperature rise and altered weather patterns. South Asia has experienced a noticeable temperature surge over the past century. The sizable population residing in the region heightens the susceptibility to the impact of global warming. In addition to affecting agriculture, water resources, and livelihood, environmental changes interfere with endocrine functioning. Resulting lifestyle changes increase the risk of metabolic and endocrine disorders. Individuals with diabetes face heightened vulnerability to extreme weather due to impaired thermoregulation. A high ambient temperature predisposes to heat-related illnesses, infertility, and nephropathy. Additionally, essential endocrine drugs and medical devices are susceptible to temperature fluctuations. The South Asian Federation of Endocrine Societies (SAFES) calls for collaboration among stakeholders to combat climate change and promote healthy living. Comprehensive approaches, including the establishment of sustainable food systems, promotion of physical activity, and raising awareness about environmental impacts, are imperative. SAFES recommends strategies such as prioritizing plant-based diets, reducing meat consumption, optimizing medical device usage, and enhancing accessibility to endocrine care. Raising awareness and educating caregivers and people living with diabetes on necessary precautions during extreme weather conditions are paramount. The heat sensitivity of insulin, blood glucose monitoring devices, and insulin pumps necessitates proper storage and consideration of environmental conditions for optimal efficacy. The inter-connectedness of global warming and endocrine disorders underscores the necessity of international collaboration guided by national endocrine societies. SAFES urges all stakeholders to actively implement sustainable practices to improve endocrine health in the face of climate change.

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