B V Bio-Corp Pvt Ltd.

VERONA, Italy--(BUSINESS WIRE)-- Sibylla Biotech today announced the successful close of its €23 million Series A financing round to fund the further development of its Pharmacological Protein Inactivation by Folding Intermediate Targeting (PPI-FIT) approach, which provides access to a new class of pharmacological targets that transiently appear during the process of protein folding, and to advance its proprietary pipeline programs through preclinical evaluation. The financing from an international syndicate of specialized life science investors was led by V-Bio Ventures with participation from Seroba Life Sciences, 3B Future Health Fund, Claris Ventures, CDP Venture Capital with Evolution Fund, VI Partners, Indaco Venture Partners, as well as the company’s seed investor, Vertis SGR. Concurrent with the close of the fundraising, Ward Capoen from V-Bio, Bruno Montanari from Seroba, Ciro Spedaliere from Claris Ventures, and Marianne Bjordal from 3B Future Health Fund will join Sibylla’s Board of Directors. “Sibylla Biotech is developing small molecule degraders designed to interfere with the folding process of a selected protein by binding to the folding intermediate states, bringing a highly differentiated approach to the protein degradation field that can access a range of targets previously considered undruggable,” commented Lidia Pieri, PhD, Co-Founder and Chief Executive Officer of Sibylla Biotech. “We have gained the support of a strong group of expert investors and the capital to advance our small molecule pipeline, expand our protein folding simulation technology platform and bring additional expertise to our team. I would like to thank all Sibylla employees, founders and supporters for enabling our achievements so far.” Through the PPI-FIT approach, Sibylla Biotech designs Folding Interfering Degraders (FIDs), classical small molecules that target specific proteins, including proteins that lack druggable pockets in their native state. The company’s lead candidate degrades Cyclin D1, a protein that is amplified and overexpressed in a range of cancers and which is currently considered an undruggable target. The proceeds of the Series A will allow the company to build out its pipeline of therapeutics by exploiting the protein folding simulation platform, as well as to further expand the potentiality of its technology. “Sibylla’s novel approach has already demonstrated that it can unlock a new category of targets with the potential to translate these into a robust pipeline of small molecule candidates for an unlimited range of indications. We are excited to support Sibylla Biotech’s vision to transform the protein degradation landscape,” added Ward Capoen, PhD, Partner at V-Bio Ventures. “Lidia and her team came together from a group of cross-disciplinary experts with the goal of developing the PPI-FIT technology. Sibylla Biotech has distinguished itself by applying ground-breaking science to solve therapeutic challenges and now they have the further validation from a group of highly experienced investors. Vertis congratulates the team on achieving this next step in their development,” said Roberto Della Marina, PhD, Operating Partner at Vertis SGR. About Sibylla Biotech Sibylla is disrupting the protein degradation landscape by applying a novel mechanism of action that interferes with protein folding and thereby suppresses the expression of a disease-relevant protein. Through their protein folding simulation technology platform, Sibylla identifies relevant and previously inexplorable folding intermediates for protein targets that are currently considered undruggable in their native state. The company is developing a proprietary pipeline of small molecule folding interfering degraders (FIDs) that can address a range of therapeutic areas. About Sibylla Biotech’s Foundation Sibylla Biotech was established as a spin-off company based on a multidisciplinary scientific collaboration between the Italian National Institute for Nuclear Physics, the University of Trento and the University of Perugia, which together co-funded the collaboration with the Telethon Foundation ETS. Vertis SGR funded the breakthrough discovery technology resulting from the collaboration, enabling the initial validation of Sibylla’s technology. For further information: For more information about Sibylla’s Investors: V-Bio Ventures: Seroba Life Sciences: 3BFuture Health Fund: Claris Venture: CDP Venture Capital – Evolution Fund: Vertis SGR: VI Partners: Indaco Venture Partners: Or visit Sibylla Biotech’s investor page: View source version on businesswire.com: Contacts Sibylla Biotech Lidia Pieri +39 347 6503353 lidia.pieri@sibyllabiotech.it Trophic Communications Valeria Fisher or Desmond James +49 175 80 41 816 or +49 1516 7859086 sibylla@trophic.eu Source: Sibylla Biotech View this news release online at:

• First Closing of V-Bio Fund 2 is announced at EUR 78 million • V-Bio Fund 2 will ensure seamless continuation of investment activities in early-stage European life sciences companies • V-Bio Ventures announces expansion of executive team, with Shelley Margetson joining as Managing Partner Ghent, Belgium, 4 February 2021 – V-Bio Ventures (V-Bio) announces today the first closing of V-Bio Fund 2 with capital commitments of EUR 78 million (USD 95 million). V-Bio Ventures will continue its prosperousrelationship as a preferred partner of VIB, a Belgium-based life sciences institute ranking among the world’s premier research organizations. VIB has a strong reputation in basic and translational life sciences research and an impressive track record in creating successful start-up companies. The new fund will build on the successful investment strategy of V-Bio Fund 1, launched in 2015. Investments of V-Bio Fund 1 have resulted in: - The creation of new start-up companies turning scientific discoveries into innovations that benefit society, including Aphea.Bio, Augustine Therapeutics and AgomAb. - The growth and internationalization of companies such as Orionis Biosciences, Confo Therapeutics and Precirix. - New experimental treatmentsreaching patients, developed by companies like Oxular, Syndesi Therapeutics and ExeVir. The aim of V-Bio Fund 2 is to create new companies which contribute to society either through effective healthcare or sustainable agriculture. The fund supports companies which either have an asset-centric focus or are based on differentiated technology platforms. V-Bio will continue to be active throughout Europe with a focus on company creation in Belgium. Most of the investors in V-Bio Fund 1 have re-joined for Fund 2, which has already exceeded the size of the first fund. Fund 2 includes a range of investor types, with the European Investment Fund (EIF) as cornerstone investor, joined by institutional investors, academic endowment funds and family offices. Shelley Margetson is joining V-Bio as Managing Partner, complementing the existing team members’ solid scientific backgrounds and expertise in investing and company building. Margetson is an experienced Senior Executive who has worked for multiple European biotechnology companies since 2001, including Merus (MRUS) which listed on the Nasdaq in 2016 with her as CFO. Her financial and deal-making expertise will contribute to the further growth of the fund and V-Bio’srespective portfolio companies. Christina Takke and Willem Broekaert, Founding Managing Partners of V-Bio, stated: “We are extremely pleased with the successful first closing of our second fund. This would not have been possible without the trust and support of our investors. Fund 2 is a testament to the successful combination of proprietary accessto top-notch science with ourteam’s collective and complementary expertise, which has proven to be a key differentiator for V-Bio.” Shelley Margetson, Managing Partner of V-Bio, added: “I am excited to have joined such an experienced organisation. V-Bio’s track record over the years has been impressive, and I look forward to making a valuable contribution to the fund by enhancing both the development of the start-ups and the investment portfolio.” Jérôme Van Biervliet, Managing Director at VIB, commented: “VIB congratulates the V-Bio team on the exciting first close of the second fund and looks forward to extending it. As a co-founder of V-Bio Ventures, and through their many investments in VIB’s start-ups, we have formed a privileged relationship. We have witnessed V-Bio Ventures become a powerful force in our biotech ecosystem, creating significant value beyond the deal. Their scientific expertise, market feedback and extensive network is of crucial value to VIB, alongside their investment capacity.” Alain Godard, EIF Chief Executive: “We are very pleased to see the first closing of V-Bio Fund 2, a testament to the hard work and success of the first V-Bio Fund. Supporting groundbreaking research, particularly in the life-sciences field, and its transition into a viable business venture is a key element in realizing Europe’s innovation potential and safeguarding the competitiveness of our economy. This is something to which the EIF attaches great importance and we are therefore very glad to be contributing to this initiative.” Koenraad van Loo, Managing Director FPIM: “The Federal Holding and Investment Company is delighted to be participating in V-Bio’s second initiative which perfectly fits within FPIM's investment framework. The team has already proven in the past that it possesses the necessary expertise and competences to get the right parties around the table and to lead the start-up companies to a next level. We are convinced that V-Bio Fund 2 will contribute to the stimulation of innovative entrepreneurship as well as the creation of highly skilled jobs, which are indispensable to the biotech eco-system and the prosperity of the Belgian economy.” Michel Casselman, CEO of the Flemish investment company PMV: “We are very pleased to continue our journey together with the enlarged V-Bio Ventures team. We consider the life sciences sector of the utmost importance for the economic development in Flanders, which has grown to become the leading European life sciences hub. We recognize the importance of innovation and value creation by companies seeking new solutions to unmet medical needs or making agriculture more sustainable. Access to finance is paramount to company creation in healthcare or sustainable agriculture. We are therefore excited to participate again in the new fund, after our successful investment in V-Bio Fund 1.” About V-Bio Ventures V-Bio Ventures ( ) is an independent venture capital firm specialized in building and financing young, innovative life science companies. V-Bio Ventures was established in 2015 and works closely with Belgium-based VIB, one of the world’s premier life science institutes. The fund invests throughout Europe in start-up and early-stage companies with high growth potential focusing on technologies that provide transformational improvements in the biotech, pharmaceutical and agricultural sectors. V-Bio Ventures’ cornerstone investor is the European Investment Fund (EIF). EIF’s contribution is supported by InnovFin Equity, with the financial backing of the European Union under Horizon 2020 Financial Instruments and the European Fund for Strategic Investments (EFSI) set up under the Investment Plan for Europe. The purpose of EFSI is to help support financing and implementing productive investments in the European Union and to ensure increased access to financing. For more information, please contact: V-Bio Ventures Christina Takke christina.takke@v-bio.ventures Willem Broekaert willem.broekaert@v-bio.ventures Shelley Margetson Shelley.margetson@v-bio.ventures