Attention to the accurate and precise measurement of the white cell (WBC) content of transfused products has risen in response to awareness of the potential benefits of WBC‐depleted components and the development of technical capabilities to produce these components. The techniques thus far reported have focused on the reliability of detecting a WBC, provided it is present in the test system. The likelihood of selecting a WBC from the product of interest for counting in the analytical system–that is, the sampling error–must also be considered. The occurrence of a WBC in a WBC‐depleted component is a rare event and may be modeled with the binomial or the Poisson distribution. Several assay techniques were analyzed by using these distribution models to determine the confidence intervals of the WBC content. The 95‐percent confidence intervals spanned more than 2 logs10 for some methods at 3 × 10(5) WBCs per product. It is concluded that the reporting of WBC content for research provides not only the estimate of the mean but also a confidence interval for this estimate. Quality control procedures should be designed to verify that the WBC content is less than the targeted amount and should provide an associated statement of confidence.

01 Jan 1990·Progress in clinical and biological research

Microbial challenge of the COBE extended life platelet set to verify that it functions as a closed system.

Article

Author: Rank, A R ; Moore, R C

01 Jan 1989·Transfusion Medicine and Hemotherapy

COBE Spectra<sup>®</sup> Apheresis System: Designs, Protocols and Results

Article

Author: Urdahl, S G

The COBE Spectra<sup>®</sup> System will perform all types of apheresis procedures. One of its main procedures is to collect single donor platelets. Because of the unique abilities of this device, the procedures are individualized by the control of several algorithms. Prior to the beginning of the run, a platelet yield is predicted using the entered platelet count. Based upon this information, changes can be made in the operating parameters to optimize the collection. Leuko-poor thrombozytes are produced which can be stored for 5 days. The collect concentration monitor, an on-line device, provides information on the use of thrombocyte concentration and yield, without the use of probes. The future of this system will ensure increased platelet yields with new channel designs or protocol modifications.

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