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01 Jul 2005·Bioorganic & medicinal chemistry lettersQ4 · MEDICINE
Rhodanine derivatives as inhibitors of JSP-1
Q4 · MEDICINE
Article
Author: O'Day, Christine ; Cutshall, Neil S. ; Prezhdo, Marina
Dual-specificity phosphatases (DSPs) are a subclass within the protein tyrosine phosphatase family (PTPs). A series of rhodanine-based inhibitors was synthesized and shown to be novel, potent, and selective inhibitors against the DSP family member JNK-stimulating phosphatase-1 (JSP-1). Compounds of this class may be useful for the treatment of inflammatory and proliferative disorders.
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