Delving into the Latest Updates on Clear Vascular, Inc. with Synapse

Overview

Basic Info

Introduction

Clear Vascular, Inc. (CVI) is a clinical stage company established in 2005 by Dr. Gilbert Gonzales, the CEO. The company has received equity and equity-sparing funding to pursue its goals of imaging and treating vulnerable plaque and other vascular inflammatory diseases. CVI has developed tin-117m based products in collaboration with the US Department of Energy and Brookhaven National Laboratory under the Initiative for Proliferation Prevention (IPP) program.

Sn-117m is a 14 day half-life gamma (159 keV) and conversion electron (130 keV) isotope that has historically been produced in reactors at low (up to 20 Ci/g) specific activities and used for bone pain palliation studies.Recently, this isotope has also found application in investigative efforts to image and treat vulnerable plaque.However, this application requires high (carrier-free) specific activity Sn-117m that can only be produced with accelerators.A new production method has, therefore, been developed that uses the Cd-116(α,3n) reaction with a 47 MeV alpha beam striking an electroplated Cd-116 target.Resulting yields were confirmed to be high (∼0.15 mCi/μAh) with minimal undesirable byproducts.An ion exchange column method was used to isolate the Sn-117m resulting in a very pure high specific activity (∼20,000 Ci/g) product.This isotope has subsequently been attached to biol. targeting mols. and used in pre-clin. and clin. studies to treat vulnerable plaque.

100 Deals associated with Clear Vascular, Inc.

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100 Translational Medicine associated with Clear Vascular, Inc.

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Pipeline

Pipeline Snapshot as of 17 Jun 2025

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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