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Last update 08 May 2025

Government College Women University Faisalabad

Education|2013|Pakistan|

www.gcwuf.edu.pk

Education|2013|Pakistan|

www.gcwuf.edu.pk

Last update 08 May 2025

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Translational Medicine

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100 Clinical Results associated with Government College Women University Faisalabad

0 Patents (Medical) associated with Government College Women University Faisalabad

840

Literatures (Medical) associated with Government College Women University Faisalabad

28 Apr 2025·International Journal of Materials Research

Eco-friendly synthesis of Cr₂O₃ nanoparticles with antioxidant, antidiabetic, and antibacterial activities

Author: Alnasir, M. Hisham ; Sajid, Muhammad ; Ali, Syed Kashif ; Nawaz, Aqsa ; Sehar, Anum ; Qamar, Muhammad Azam ; Farhan, Ahmad ; Arooj, Yusra ; Sarfraz, Raja Adil

AbstractMetal nanoparticles synthesized by the green method show remarkably different properties from bulk materials due to their size, especially in biological applications. The study’s objective is to lessen the adverse effects of synthesis processes, the chemicals they use, and the derivative substances that come from them. One practical approach in green nanotechnology is the use of various biomaterials for the synthesis of nanoparticles. In the present study, chromium nanoparticles were fabricated using Fagonia indica (LEFI) leaf extract as a reducing agent. This technique produced 46 nm-sized nanoparticles that are not only highly stable but also hold promise for a range of applications. The synthesized nanoparticles were characterized by X-ray diffraction spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, dynamic light scattering, Fourier transform infrared spectroscopy, and ultraviolet–visible spectroscopy. An alpha-amylase assay was used to determine the antidiabetic potential of the nanoparticles. The antioxidant activity of plant extract and chromium nanoparticles was evaluated using 2,2-Diphenyl-1-picrylhydrazyl scavenging activity. The agar diffusion method was used to test how well chromium nanoparticles killed Staphylococcus aureus and Escherichia coli. The study’s findings indicate that Cr2O3 nanoparticles have potential as physiologically active agents for bio-medicinal uses, providing reassurance for their future use.

01 Apr 2025·Molecular Diversity

Virtual screening, ADME prediction, drug-likeness, and molecular docking analysis of Fagonia indica chemical constituents against antidiabetic targets

Article

Author: Parveen, Shagufta ; Riaz, Rabia ; Ali, Awais ; Rashid, Maryam ; Shafiq, Nusrat

Fagonia indica from Zygophyllaceae family is a medicinal specie with significant antidiabetic potential. The present study aimed to investigate the in vitro antidiabetic activity of Fagonia indica crude extract followed by an in silico screening of its phytoconstituents. For this purpose, crude extract of Fagonia indica was prepared and divided in three different parts, i.e., n-hexane, ethyl acetate, and methanolic fraction. Based on in vitro outcomes, the phytochemical substances of Fagonia indica were virtually screened through a literature survey and a screening library of compounds (1-13) was prepared. The clinical potential of these novel drug candidates was assessed by applying an ADME screening profile. Findings of SwissADME indicators (Absorption, Distribution, Metabolism, and Excretion) for the compounds (1-13) presented relatively optimal physicochemical characteristics, drug-likeness, and medicinal chemistry. The antidiabetic action of these leading drug candidates was optimized through molecular docking analysis against 3 different human pancreatic α-amylase macromolecular targets with (PDB ID 1B2Y), (PDB ID 3BAJ), and (PDB ID: 3OLI) by applying Virtual Docker (Molegro MVD). Metformin was taken as a reference standard for the sake of comparison. In vitro antidiabetic evaluation gave good results with promising α-amylase inhibitory action in the form of IC₅₀ values, as for n-hexane extract = 206.3 µM, ethyl acetate = 41.64 µM, and methanolic extract = 9.61 µM. According to in silico outcomes, all 13 phytoconstituents possess the best binding affinity with successful MolDock scores ranging from - 97.2003 to - 65.6877 kcal/mol and show a great number of binding interactions than native drug metformin. Therefore, the current work concluded that the diabetic inhibition prospective of extract and the compounds of Fagonia indica may contribute to being investigated as a new class of antidiabetic drug or drug-like candidate for further studies.

01 Apr 2025·Experimental Parasitology

A step forward to revolutionize the eimeriosis controlling strategies in cattle by using traditional medication

Review

Author: Parveen, Asia ; Zulqarnain, Muhammad ; Sarfaraz, Muhammad Zahid ; Zaman, Muhammad Arfan ; Kousar, Safina ; Abbas, Sidra

More than 10 species of Eimeria is found in cattle but Eimeria zuernii is one of the most pathogenic protozoan parasites affecting the global livestock industry. At the herd level, E. zuernii can cause illness in 10-80% of animals and reduce gross margins by 8-9%, leading to estimated annual losses of $731 million. This review highlights the economic impact, prevalence, and current control methods for E. zuernii infections, as well as the challenges associated with treatment and the development of alternative control methods. In the past two decades, 22 studies have examined synthetic drugs for managing eimeriosis in cattle. Various anticoccidial drugs (AcDs; Amprolium, decoquinate, ionophores, monensin, lasalocid, toltrazuril etc) have been used, but the efficacy of these drugs is no more consistent. Because of this, E. zuernii develops resistance to some of these anticoccidials. This trend highlights the urgent need for alternative treatments. The medicinal plants being enriched with various phytochemicals like flavonoids, tannins, alkaloids, terpenes etc have been reported as potential anticoccidial, anthelmintic and antimicrobial efficacy against the different parasites including Eimeria species in chicken, pig and rabbits. However, this review suggests the research community to treat the E. zuernii with a plant based medication (oils and extracts). This review critically emphasizes the need to acknowledge the significant role of medicinal plants in controlling eimeriosis and also the large-scale trials or standardization of plant-based therapies is required. By incorporating plant-based remedies into integrated treatment strategies alongside synthetic drugs and improved sanitation practices, we can effectively minimize financial losses and safeguard livestock health.

100 Deals associated with Government College Women University Faisalabad

100 Translational Medicine associated with Government College Women University Faisalabad

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Government College Women University Faisalabad

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