Purification method for preparation of edoxaban intermediate, i.e., ethyl-2-[(5-chloropyridine-2- yl)amino]-2-oxoacetate hydrochloride formula using the alc. solvent at reflux condition was reported.The purity of edoxaban intermediate was increased by implementing these manufacturing processes.The process provided in the present invention involved convenient operations and high purity efficiency (<99%).The process was environmental-friendly and suitable for com. scale.