Caris Life Sciences, Inc.

The University of Chicago Medicine Comprehensive Cancer Center joins Caris' extensive network of leading cancer institutions committed to utilizing clinical data to advance patient care and outcomes IRVING, Texas, March 8, 2023 /PRNewswire/ -- Caris Life Sciences®(Caris), the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare, announced today that the University of Chicago (UChicago) Medicine Comprehensive Cancer Center has joined the Caris Precision Oncology Alliance™ (POA). The POA is a growing network of leading cancer centers across the globe that collaborate to advance precision oncology and biomarker-driven research. POA members work together to establish and optimize standards of care for molecular testing through innovative research focused on predictive and prognostic markers that improve the clinical outcomes for cancer patients. The Caris Precision Oncology Alliance includes 79 cancer centers and academic institutions. The UChicago Medicine Comprehensive Cancer Center includes more than 200 cancer specialists who offer innovative treatments, leading-edge research and clinical trials not available elsewhere in the Midwest. UChicago Medicine scientists study disease at the molecular level and clinical researchers apply the knowledge discovered in the institution's laboratories to create and test promising new cancer treatments and procedures. The academic health system's physician-scientists also specialize in cancer control, prevention and population research while implementing new approaches to screening and prevention. The institution is one of two NCI-designated comprehensive cancer centers in Illinois and a key part of its mission is community research to eliminate health disparities between ethnic and social groups. "As home to a National Cancer Institute-designated Comprehensive Cancer Center, UChicago Medicine is excited to join colleagues across the country in this collaborative effort to advance precision medicine," said Walter M. Stadler, M.D., Senior Advisor to the Director of the UChicago Medicine Comprehensive Cancer Center and Dean for Clinical Research. "We look forward to working with colleagues throughout the country to translate genomic data into better care for cancer patients here in Chicago and around the world." "We are excited to welcome the UChicago Medicine Comprehensive Cancer Center to the growing Precision Oncology Alliance network," said Chadi Nabhan, M.D., MBA, FACP, Chairman of the Caris Precision Oncology Alliance. "As a former UChicago Medicine faculty member, I know firsthand the dedication its physicians and researchers have to providing the most advanced and innovative therapies available to their patients. Our missions are the same – to improve the outcomes of all patients suffering from cancer through precision medicine." The Caris Precision Oncology Alliance includes 79 cancer centers and academic institutions. These institutions have early access to the extensive database and artificial intelligence platform within Caris to establish evidence-based standards for cancer profiling and molecular testing in oncology. By leveraging the comprehensive genomic, transcriptomic and proteomic profiling available through Caris molecular profiling, Caris seeks to provide this network with the ability to prioritize therapeutic options and determine which clinical trial opportunities may benefit their patients. POA members are also able to integrate with a growing portfolio of biomarker directed trials sponsored by biopharma. Additionally, as a member of the POA, institutions have access to Caris CODEai™, the most comprehensive data solution in the industry with cancer treatment information and clinical outcomes data for over 350,000 patients covering over 1 million data points per patient. About Caris Life Sciences Caris Life Sciences® (Caris) is the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare and improve patient outcomes. Through comprehensive molecular profiling (Whole Exome and Whole Transcriptome Sequencing) and the application of advanced artificial intelligence (AI) and machine learning algorithms, Caris has created the large-scale clinico-genomic database and cognitive computing needed to analyze and unravel the molecular complexity of disease. This information provides an unmatched resource and the ideal path forward to conduct the basic, fundamental research to accelerate discovery for detection, diagnosis, monitoring, therapy selection and drug development to improve the human condition. With a primary focus on cancer, Caris' suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps patients, physicians and researchers better detect, diagnose and treat patients. The company's latest advancement, Caris Assure™, is a blood-based, circulating nucleic acids sequencing (cNAS) assay that combines comprehensive molecular analysis (Whole Exome and Whole Transcriptome Sequencing from blood) and serial monitoring – making it the most powerful liquid biopsy assay ever developed. Headquartered in Irving, Texas, Caris has offices in Phoenix, New York, Tokyo, Japan and Basel, Switzerland. Caris or its distributors provide services in the U.S., Europe, Asia and other international markets. To learn more, please visit CarisLifeSciences.com or follow us on LinkedIn. About the University of Chicago Medicine Comprehensive Cancer Center The mission of the University of Chicago Medicine Comprehensive Cancer Center is to discover the determinants of cancer, develop novel therapies for cancer, and prevent cancer through innovative and collaborative research, compassionate patient care, education, and community engagement. The UChicago Medicine Cancer Center has been listed in U.S. News & World Report as one of "America's Best Hospitals" for cancer since 1999. Learn more at . Caris Life Sciences Media Contact: Lisa Burgner corpcomm@carisls.com 214.294.5606 University of Chicago Medicine Comprehensive Cancer Center Media Contact: Ashley Heher Ashley.Heher@uchicagomedicine.org 773.726.8746

IRVING, Texas, March 7, 2023 /PRNewswire/ -- Caris Life Sciences®(Caris), the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare, today announced a strategic research partnership with Incyte Corporation (NASDAQ:INCY) to augment precision medicine approaches for Incyte's oncology pipeline. This partnership with Incyte will leverage Caris' leading molecular science and technology solutions Caris' unique platform combines data from whole exome sequencing, whole transcriptome sequencing, protein analysis, and proprietary AI models and signatures to improve patient outcomes through advancement of personalized medicine. The partnership will apply Caris' data and analytics tools, comprehensive molecular tissue and liquid profiling services, and clinical trial enrollment program capabilities across two therapeutic programs initially, with the option for Incyte to expand to four total programs. "This partnership with Incyte will leverage Caris' leading molecular science and technology solutions to support Incyte's oncology research and development efforts," said David Spetzler, M.S., Ph.D., MBA, President and Chief Scientific Officer of Caris Life Sciences. "The aggregate strength of our platform, which provides patient level DNA and RNA data both in tissue and blood, may help to better identify and predict patient response to therapy, which in turn may accelerate clinical trial enrollment, optimize clinical positioning and potentially enhance technical and regulatory success." Under the terms of the agreement, Incyte will leverage Caris' data insights and analytics capabilities to discover novel biomarkers and optimize clinical positioning strategies for its oncology programs. For drug candidates developed under the collaboration, patients enrolled in Incyte-led clinical trials will undergo longitudinal testing with Caris' comprehensive tissue and liquid molecular profiling assays. Incyte will also leverage Caris' biomarker-driven patient selection for clinical trials including options to partner on developing companion diagnostics for programs in the partnership. "Incyte is committed to identifying new treatments for cancer patients using approaches exploring both single agents and combinations of targeted therapies and immunotherapies in areas of high unmet medical need," said Jeff Jackson, Ph.D., Vice President, Translational Sciences at Incyte. "Our partnership with Caris will bring a comprehensive suite of precision medicine capabilities to augment Incyte's success in developing key programs in our robust oncology portfolio." About Caris Life Sciences Caris Life Sciences® (Caris) is the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare and improve patient outcomes. Through comprehensive molecular profiling (Whole Exome and Whole Transcriptome Sequencing) and the application of advanced artificial intelligence (AI) and machine learning algorithms, Caris has created the large-scale clinico-genomic database and cognitive computing needed to analyze and unravel the molecular complexity of disease. This information provides an unmatched resource and the ideal path forward to conduct the basic, fundamental research to accelerate discovery for detection, diagnosis, monitoring, therapy selection and drug development to improve the human condition. With a primary focus on cancer, Caris' suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps patients, physicians and researchers better detect, diagnose and treat patients. The company's latest advancement, Caris Assure™, is a blood-based, circulating nucleic acids sequencing (cNAS) assay that combines comprehensive molecular analysis (Whole Exome and Whole Transcriptome Sequencing from blood) and serial monitoring – making it the most powerful liquid biopsy assay ever developed. Headquartered in Irving, Texas, Caris has offices in Phoenix, New York, Tokyo, Japan and Basel, Switzerland. Caris or its distributors provide services in the U.S., Europe, Asia and other international markets. To learn more, please visit CarisLifeSciences.com or follow us on LinkedIn. Caris Life Sciences Media Contact: Lisa Burgner corpcomm@carisls.com 214.294.5606 Caris Life Sciences Business Development Contact: Brian Lamon, Ph.D. Chief Business Officer, Head of BioPharma Business Development blamon@carisls.com 609.955.8883 Company Codes: NASDAQ-NMS:INCY

Research results from five studies across three solid tumor types demonstrate the impact of Caris' approach to molecular profiling across the continuum of cancer care IRVING, Texas, Feb. 13, 2023 /PRNewswire/ -- Caris Life Sciences®(Caris), the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare, today announced that the company and partners within the Caris Precision Oncology Alliance™ (POA) will collectively present five studies across three tumor types at the 2023 American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium, February 16-18, 2023 in San Francisco (Tabletop #50). "We are proud of the growing number of collaborative abstracts accepted for presentation at ASCO GU, demonstrating the power of Caris' comprehensive molecular profiling and the large-scale collaboration between POA sites," said Chadi Nabhan, M.D., MBA, FACP, Chairman of the Caris Precision Oncology Alliance. "The findings represent important observations in prostate, urothelial, and renal cancers, which could lead to novel treatment strategies and knowledge that improve patient outcomes." "At Caris, our goal is to enable clinicians to make the best treatment choices for their patients, researchers to discover new targets, and the biopharmaceutical industry to develop the next breakthrough medicines," said David Spetzler, M.S., Ph.D., MBA, President and Chief Scientific Officer of Caris. "These presentations show how our physicians, scientists and partners in the POA are leveraging real-world clinical evidence from over 455,000 lifetime cases in Caris' unique AI-driven platform to deepen our understanding of cancer. These foundational discoveries provide key insights into advanced cancer and support the development of precision oncology approaches in advanced genitourinary tumors to better serve cancer patients." Poster presentations include: Clinical and Molecular Features of ATM and BRCA2 Mutations in Metastatic Prostate Cancer. (Poster Number: J8) February 16, 11:30 AM – 1:00 PM PST The Genomic Landscape of Urothelial Carcinoma with High and Low ERBB2/HER2 Expression. (Poster Number: M18) February 17, 12:30 – 2:00 PM PST Characterization and Impact of Wnt5A Signaling on Outcomes of Urothelial Carcinoma. (Poster Number: N3) February 17, 12:30 – 2:00 PM PST Exploration of Immunosuppressive Features of the Tumor Microenvironment within Hepatic and Non-Hepatic Tumors of Urothelial Origin. (Poster Number: N5) February 17, 12:30 – 2:00 PM PST Characterization of FOLH1 Expression in Renal Cell Carcinoma (RCC). (Poster Number: K8) February 18, 7:00 – 8:00 AM PST Poster and abstract summaries highlighting this research will be available onsite at Caris' Tabletop #50. The full abstracts will be available through the official ASCO website February 13. The Caris Precision Oncology Alliance includes 77 cancer centers and academic institutions in the United States and beyond. These institutions have early access to the extensive database and artificial intelligence platform within Caris to establish evidence-based standards for cancer profiling and molecular testing in oncology. By leveraging the comprehensive genomic, transcriptomic and proteomic data available through Caris molecular profiling, Caris seeks to provide this network with the ability to prioritize therapeutic options and determine which clinical trial opportunities may benefit their patients. POA members are also able to integrate with a growing portfolio of biomarker directed trials sponsored by biopharma. Additionally, as a member of the POA, institutions have access to Caris CODEai™, the most comprehensive data solution in the industry with cancer treatment information and real-world clinical outcomes evidence for over 350,000 patients covering over 1 million data points per patient. About Caris Life Sciences Caris Life Sciences® (Caris) is the leading molecular science and technology company actively developing and delivering innovative solutions to revolutionize healthcare and improve patient outcomes. Through comprehensive molecular profiling (Whole Exome and Whole Transcriptome Sequencing) and the application of advanced artificial intelligence (AI) and machine learning algorithms, Caris has created the large-scale clinico-genomic database and cognitive computing needed to analyze and unravel the molecular complexity of disease. This information provides an unmatched resource and the ideal path forward to conduct the basic, fundamental research to accelerate discovery for detection, diagnosis, monitoring, therapy selection and drug development to improve the human condition. With a primary focus on cancer, Caris' suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps patients, physicians and researchers better detect, diagnose and treat patients. The company's latest advancement, Caris Assure™, is a blood-based, circulating nucleic acids sequencing (cNAS) assay that combines comprehensive molecular analysis (Whole Exome and Whole Transcriptome Sequencing from blood) and serial monitoring – making it the most powerful liquid biopsy assay ever developed. Headquartered in Irving, Texas, Caris has offices in Phoenix, New York, Tokyo, Japan and Basel, Switzerland. Caris provides services throughout the U.S., Europe, Asia and other international markets. To learn more, please visit CarisLifeSciences.com or follow us on LinkedIn. Caris Life Sciences Media Contact: Lisa Burgner [email protected] 214.294.5606 SOURCE Caris Life Sciences