Anhui Shuobai Pharmaceutical Technology Co Ltd

Primary purpose: To evaluate the safety of JKN2304 inhalation solution in COPD patients Secondary purpose: 1) To evaluate the effectiveness of JKN2304 inhalation solution in COPD patients 2) To evaluate the pharmacokinetic characteristics of JKN2304 inhalation solution in COPD patients

Primary purpose: To evaluate the safety of JKN23041 inhalation solution at different doses in COPD patients; Secondary purpose: 1) To evaluate the effectiveness of JKN23041 inhalation solution at different doses in COPD patients; 2) To evaluate the pharmacokinetic characteristics of JKN23041 inhalation solution in COPD patients.

To evaluate the safety and tolerability of multiple inhalation administration of DBM-1152A inhalation solution in healthy Chinese subjects. To evaluate the pharmacokinetic characteristics of multiple inhalation administration of DBM-1152A inhalation solution in healthy Chinese subjects. To evaluate the C-QTc relationship after multiple administration of DBM-1152A inhalation solution in healthy Chinese subjects.