The effect of nipradilol on the isoproterelol-induced depression of contractions of the soleus muscle of the anesthetized cats was studied. Isoproterenol (0.3 microg/kg) injected intravenously decreased the tension and degree of fusion of incomplete tetanic contractions of the soleus muscle of the anesthetized cats. The effect of isoproterenol was blocked by nipradilol (> or = 3 microg/kg), desnitro-nipradilol (> or = 10 microg/kg) and propranolol (> or = 10 microg/kg), but not by nitroglycerin (10-100 microg/kg). Nipradilol (30 microg/kg) and desnitronipradilol (300 microg/kg) almost completely antagonized the depressor effects of isoproterenol. These results coupled with evidence that nipradilol does not penetrate the blood-brain barrier indicate that nipradilol exerts an anti-tremor action by blocking peripheral beta2-adrenoceptors.

01 Jan 1998·Soil and Aquifer Pollution

Overview of NAPL Contamination and Reclamation

Author: J. B. Carberry ; H. Rubin ; N. Narkis

Groundwater represents the major source of drinking water in most parts of the world. In Israel about 60% of the water supply comes from aquifers. For many years the public’s interest with regard to water needs was concerned with the availability of sufficient quantities of groundwater. In arid and semiarid regions there is an increasing need for adequate storage in which water surplus in wet seasons can be diverted for use in dry seasons. It has been shown that in most cases groundwater aquifers represent the best option for water storage. Therefore, references to groundwater resources include the quantity of groundwater as well as the capacity of the aquifers to store water.

01 Jan 1995·DrugsQ1 · MEDICINE

Evaluation of Photosensitising Ability of Quinolones in Guinea-Pigs

Q1 · MEDICINE

Article

Author: Mikako Ishihara ; Kohachi Kamada ; Takeshi Horio ; Akihiko Ogawa ; Tatsumi Inoue

In guinea pigs, lomefloxacin, fleroxacin, and sparfloxacin all induced phototoxicity at concentrations that may be clin. relevant in humans.All three quinolones also produced a weak photoallergic reaction.

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