HepatoChem, Inc.

Herein the authors disclose the authors' study toward the synthesis of aryl phosphonates using either photocatalytic conditions or a photoinduced process.First, a phosphonylation reaction catalyzed by a Cu complex was developed in batch, but unfortunately, it was not efficient under continuous flow.Alternatively, a photoinduced phosphonylation reaction was developed in continuous flow with a moderate efficiency.Finally, to enhance the yields observed under the continuous flow conditions for the scale-up, a complementary approach using another com. available photoreactor was suggested to tackle the modest productivity observed in continuous flow.