This work describes the chem. study of two medicinal plants of the Amazon, Philodendron scabrum K. Krause (Araceae) and Vatairea guianensis Aubl. (Fabaceae).Essential oils composition from stems of Philodendron scabrum K. Krause (Araceae) and fruits of Vatairea guianensis Aubl. (Fabaceae), resp. were analyzed in GC-FID and GC-MS.The major constituents from stems of P. scarabum were caryophyllene oxide (22.42%), α-copaene (16.08%) and β-bisabolene (12.01%) and from fruits of V. guianensis were (9Z)-octadecenoic acid (24.95%) and docosahexaenoic acid (24.17%).β-Sitosterol and alkylresorcinol 1-hexadecanoyl-2,6-dihydroxybenzene were isolated from ethanolic extracts from stems of P. scabrum and from ethanolic extracts from fruits of V. guianensis, the athraquinones chrysophanol and physcion were isolated.The structure of isolated compounds we determinate were based on data from 1H and 13C NMR, including two dimensional analyses and comparison with literature data.