Five 3',5'-di-O-acylribonucleosides were converted into the corresponding β-D-arabinofuranosyl derivatives in 38-70% yields by DMSO-oxidation followed by NaBH₄-reduction and deacylation with NaOMe-MeOH, e.g., adenosine (I; R = Bz, R¹ = OH, R² = H) by sequential oxidation, reduction, and deacylation gave 66% I (R = R¹ = H, R² = OH).

01 Jan 1981·Biomedical Research

<b>Effects of histamine, carbachol and gastrin on oxygen uptake in isolated mammalian parietal </b><b>cells </b>

Author: MATSUO, YUTAKA ; OSADA, EIZABURO

The effect of histamine [51-45-6], carbachol [51-83-2], and gastrin [9002-76-0] on O uptake in parietal cells isolated from guinea pig fundic mucosa was studied.Viable mucosal cells were prepared by exposure of the separated mucosa sequentially to low concentrations of collagenase and dispase.The viability of parietal cells was >95% and the purity was 70%.Increase in O uptake of parietal cells in response to the secretagogues was measured by polarog. in the absence of isobutylmethylxanthine.A dose-response relation was obtained for histamine in the range 10^-9-10^-6M, and for gastrin at 10^-12-10^-9M.The maximum response was observed at 10^-6M with a 30% increase for histamine, at 10^-8M with a 40% increase for carbachol and at 10^-9M with a 30% increase for gastrin.For each of these secretagogues, an inhibition was observed following the concentration which showed the maximum response.

01 Jan 1980·The Journal of AntibioticsQ4 · MEDICINE

A new antibiotic, antlermicin A.

Q4 · MEDICINE

Article

Author: Taku Mizuno ; Kimie Kobinata ; Kiyoshi Isono ; Masakazu Uramoto

A new antibiotic, antlermicin A (I) [73666-84-9], was produced by fermentation with Micromonospora chlacea kazunoensis.I is active against Bacillus subtilis.Other gram-pos. bacteria are less sensitive, and the gram-neg. bacteria, mycobacteria, yeasts, and fungi tested were not affected.I was toxic to Yoshida sarcoma cells.I is acidic, has a mol. weight ∼1300, and seems to be an ionophore.

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