The 2-acetylfuran was prepared by Friedel-Crafts acylation with catalyst of phosphoric acid, refluxing for 5 h, using furan and acetic anhydride as raw material.The reaction yield was 58%.The product was characterized and confirmed by IR spectroscopy.

Huaxue Gongchengshi

Synthesis of hippuric acid

Author: Wang, Li-ye ; Wang, Hong-sheng ; Li, Gong-chun ; Liu, Ya-jun

Hippuric acid was synthesized by acylation of glycine using benzoyl chloride under condition of sodium hydroxide solutionThe reaction yield was 74.4%.

Fenxi Ceshi Xuebao

Preparation and application of diazepam molecularly imprinted polymers

Author: Chen, Hui-min ; Jia, Yu-xiang ; Zhu, Ruo-hua

Molecularly imprinted polymer materials were prepared by bulk polymerization and precipitation polymerization methods using diazepam as template mol., and effects of crosslinker, porogen agent and temperature on the properties of polymer materials were optimized.The molecularly imprinted microspheres were synthesized with divinylbenzene(DVB) as cross-linker and acetonitrile as porogen agent.The polymer prepared by bulk polymerization showed irregular shape, while the microspheres prepared by precipitation polymerization were regular in SEM image.The binding capacity and selective characteristics of the molecularly imprinted polymer were investigated by equilibrium binding experimentsIt showed that the maximum adsorption to diazepam of the molecularly imprinted microspheres was up to 130μg/g and the adsorption to oxazepam and nitrazepam was about 110μg/g.The results showed that the imprinted polymer exhibited higher adsorptivity and selectivity for diazepam compared with the non-imprinted polymers.In addition, the molecularly imprinted polymer was used as solid phase extraction sorbent in solid-phase extraction column to isolate diazepam in feed and pig urine samples for its excellent identifying characteristics.High performance liquid chromatog.(HPLC) was employed to detect three drugs.The method showed good linearities in the range of 0.1-20 mg/L for oxazepam, nitrazepam and diazepam, with correlation coefficients of 0.9996-0.9999 and detection limits(S/N=3) of 0.03-0.08 mg/L.The recoveries of three drugs in feed and pig urine were in the range of 71%-79% and 66%-71%, resp.The proposed method provides a new way for the detection of antipsychotic drugs.

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