Author: Stoletniy, Liset ; Abramov, Dmitry ; Basir, Mir B. ; Khedr, Mohamed ; Basir, Mir B ; Brilakis, Emmanouil S. ; Sedhom, Ramy ; Beshai, Rafail ; Megaly, Michael ; Bharadwaj, Aditya ; Alaswad, Khaldoon ; Brilakis, Emmanouil S

PURPOSE:

To examine the characteristics and outcomes of myocardial infarction (MI) among burn patients.

MATERIALS AND METHODS:

The Nationwide Readmissions Database was utilized to identify hospitalizations of patients with burns from 2016 to 2020. The main outcome was the difference in all-cause in-hospital mortality between burn patients with and without MI.

RESULTS:

Of 200,130 hospitalizations with burns, 1997 (1 %) developed acute MI. Burn patients with MI were older, more likely to be men, and had a higher prevalence of cardiovascular risk factors. Only burns affecting the trunk and respiratory tract, and those affecting > 20 % of body surface area (BSA), were associated with an increased risk of MI. All-cause in-hospital mortality was higher among patients with MI (18.7 % vs. 3 %, adjusted odds ratio (aOR) 4.59, 95 % confidence interval (CI) 3.66, 5.76). Cardiogenic shock, ventricular tachycardia, and stroke rates were higher among patients with MI. Revascularization was associated with lower in-hospital mortality (aOR 0.33, 95 % CI 0.17, 0.64) CONCLUSIONS: The incidence of MI in burn patients is low but is associated with high mortality and morbidity. Burns involving the trunk and respiratory tract, and those affecting > 20 % BSA, were associated with an increased risk of MI. Revascularization was associated with lower in-hospital mortality.

01 Feb 2025·World Neurosurgery

Machine Learning Algorithms for Neurosurgical Preoperative Planning: A Scoping Review

Review

Author: Bertani, Raphael ; Rios-Garcia, Wagner ; Colan, Jhair Alejandro ; Neves Ferreira, Julia Sader ; Pariasca Trevejo, Emanuel Eduardo Franco ; Rojas-Apaza, Rolando ; Bocanegra-Becerra, Jhon E ; Lopez-Gonzalez, Miguel Angel ; Eraghi, Mohammad Mirahmadi ; Castilla-Encinas, Adriam M ; Simoni, Gabriel ; Hong, Anthony

BACKGROUND AND OBJECTIVE:

Preoperative neurosurgical planning is an important step in avoiding surgical complications, reducing morbidity, and improving patient safety. The incursion of machine learning (ML) in this domain has recently gained attention, given the notable advantages in processing large datasets and potentially generating efficient and accurate algorithms in patient care. We explored the evolving applications of ML algorithms in the preoperative planning of brain and spine surgery.

METHODS:

In accordance with the Arksey and O'Malley framework, a scoping review was conducted using 3 databases (PubMed, Embase, and Web of Science). Articles that described the use of ML for preoperative planning in brain and spine surgery were included. Relevant data were collected regarding the neurosurgical field of application, patient baseline features, disease description, type of ML technology, study's aim, preoperative ML algorithm description, and advantages and limitations of ML algorithms.

RESULTS:

Our search strategy yielded 7407 articles, of which 8 studies (5 retrospective, 2 prospective, and 1 experimental) satisfied the inclusion criteria. Clinical information from 518 patients (62.7% female; mean age: 44.8 years) was used for generating ML algorithms, including convolutional neural networks (14.3%), logistic regression (14.3%), and random forest (14.3%), among others. Neurosurgical fields of applications included functional neurosurgery (37.5%), tumor surgery (37.5%), and spine surgery (25%). The main advantages of ML included automated processing of clinical and imaging information, selection of an individualized patient surgical approach, and data-driven support for treatment decision-making. All studies reported technical limitations, such as long processing time, algorithmic bias, limited generalizability, and the need for database updating and maintenance.

CONCLUSIONS:

ML algorithms for preoperative neurosurgical planning are being developed for efficient, automated, and safe treatment decision-making. However, future studies are necessary to validate their objective performance across diverse clinical scenarios. Enhancing the robustness, transparency, and understanding of ML applications will be crucial for their successful integration into neurosurgical practice.

01 Jan 2025·AMERICAN SURGEON

Tranexamic Acid and Pulmonary Complications: A Secondary Analysis of an EAST Multicenter Trial

Article

Author: Jacobson, Lewis E. ; Chang, Grace ; Nordham, Kristen D. ; Tatar, Antony ; Coleman, Lauren E. ; Vella, Michael ; Bernard, Andrew C. ; Lightwine, Kelly L. ; Haan, James M. ; Murry, Jason ; Bird, Emily ; Okafor, Barbara ; Anderson, Christofer ; Etchill, Eric ; Burruss, Sigrid ; Carrick, Matthew M. ; Noorbakhsh, Matthew R. ; Maluso, Patrick ; Norwood, Scott H. ; Nelson, Marsha C. ; Reeves, Matthew ; Whittenburg, Laura ; Goldberg, Amy J. ; Ninokawa, Scott ; Fang, Raymond ; Bugaev, Nikolay ; Tatebe, Leah ; Babowice, James ; LaRiccia, Aimee ; Mendiola Pla, Michelle ; Lieser, Mark J. ; Mederos, Dalier R. ; Taghavi, Sharven ; Haut, Elliott R. ; Gamber, Mark A. ; Maher, Zoe ; Shatz, David V. ; Raza, Shariq S. ; Keating, Jane ; Dellonte, Kate ; Hayward, Thomas Z. ; Tatum, Danielle ; Berne, John D. ; Toraih, Eman ; Duchesne, Juan ; Roche, Samantha L. ; Holler, Emma ; Broome, Jacob M. ; Askari, Reza ; Spalding, Chance ; Williams, Jamie ; Bhupathi, Apoorva ; Goldenberg-Sandau, Anna

Background:

Anti-inflammatory effects of tranexamic acid (TXA) in reducing trauma endotheliopathy may protect from acute lung injury. Clinical data showing this benefit in trauma patients is lacking. We hypothesized that TXA administration mitigates pulmonary complications in penetrating trauma patients.

Materials and Methods:

This is a post-hoc analysis of a multicenter, prospective, observational study of adults (18+ years) with penetrating torso and/or proximal extremity injury presenting at 25 urban trauma centers. Tranexamic acid administration in the prehospital setting or within three hours of admission was examined. Participants were propensity matched to compare similarly injured patients. The primary outcome was development of pulmonary complication (ARDS and/or pneumonia).

Results:

A total of 2382 patients were included, and 206 (8.6%) received TXA. Of the 206, 93 (45%) received TXA prehospital and 113 (55%) received it within three hours of hospital admission. Age, sex, and incidence of massive transfusion did not differ. The TXA group was more severely injured, more frequently presented in shock (SBP < 90 mmHg), developed more pulmonary complications, and had lower survival ( P < 0.01 for all). After propensity matching, 410 patients remained (205 in each cohort) with no difference in age, sex, or rate of shock. On logistic regression, increased emergency department heart rate was associated with pulmonary complications. Tranexamic acid was not associated with different rate of pulmonary complications or survival on logistic regression. Survival was not different between the groups on logistic regression or propensity score–matched analysis.

Conclusions:

Tranexamic acid administration is not protective against pulmonary complications in penetrating trauma patients.

News (Medical) associated with Loma Linda University Medical Center

03 Dec 2024

·www.prnewswire.com

Barbara Sinatra Children's Center Breaks Ground on New Wing to Expand Forensic Medical Services to Survivors of Abuse

Services in the Pavilion for Child and Adolescent Health made possible through a partnership with San Manuel Band of Mission Indians and Loma Linda University Children's Hospital RANCHO MIRAGE, Calif., Dec. 3, 2024 /PRNewswire/ -- Today, the Barbara Sinatra Children's Center (BSCC) broke ground on a new wing of its facility to expand the Center's forensic medical services to patients ages 18 and under. The Pavilion for Child and Adolescent Health expansion project is expected to be complete in early 2026. The new wing is part of the Barbara Sinatra Children's Center Foundation's $10 million "Passion to Prevent" campaign, which has reached 70% of their goal and now enters the public phase of the campaign. Continue Reading Barbara Sinatra Children’s Center Breaks Ground on New Wing to Expand Forensic Medical Services to Survivors of Abuse In anticipation of this new wing coming online, the San Manuel Band of Mission Indians (SMBMI) has provided a $500,000 grant to increase forensic medical capacity at the Center with Loma Linda University Children's Hospital personnel. This new wing will support additional forensic medical examinations for children and adolescents due to suspected sexual or physical abuse, along with follow-up medical exams for abuse survivors and mandated foster care medical exams. Funds from the Tribe's grant will support additional pediatricians, pediatric nurse practitioners and pediatric fellows from Loma Linda University Children's Hospital who are providing these services. "At the Center, we are dedicated to ensuring the safety and security of children around the world, and providing proper forensic services is a crucial part of that mission," said Director and CEO of Barbara Sinatra Children's Center, John Thoresen. "We are honored and so grateful to our partnership with San Manuel Band of Mission Indians and Loma Linda University Children's Hospital to assist us as we work to increase the level of care we can provide to our patients." The Pavilion for Child and Adolescent Health at the Barbara Sinatra Children's Center will include three new exam rooms and provide a space to house medical staff and the staff of the Riverside County Coalition to End Human Trafficking. "Healthy and resilient communities start with making sure that children have access to services that will keep them safe and cared for," said Chairwoman Lynn Valbuena, San Manuel Band of Mission Indians. "Together, we are bringing critical resources to youth in the Coachella Valley. We look forward to the creation of a safe, compassionate space for pediatric forensic services." The Tribe has a shared mission to ensure the health and wellbeing of children in the Southern California region and has a longstanding relationship with Loma Linda University Hospital. San Manuel Band of Mission Indians will now extend that same support and generosity to the Barbara Sinatra Children's Center and leverage its partnership with Loma Linda University Hospital to help bring more services and support to children in need. "Loma Linda University Children's Hospital is eager to provide our services to further the Barbara Sinatra Children's Center's mission," said Amy Young, MD Loma Linda University Children's Hospital and the new BSCC Medical Director. "Our pediatric staff is ready to care for these young patients in the new BSCC wing as we work to extend our reach into the Coachella Valley for those in need." To learn more about the new wing expansion project at the Barbara Sinatra Children's Center as well as the services provided by the Center, please visit BarbaraSinatraChildrensCenter.org . About the Barbara Sinatra Children's Center (BSCC): Founded in 1986 by Barbara and Frank Sinatra, the Barbara Sinatra Children's Center is dedicated to ensuring every child's right to a normal, healthy and secure childhood. Since its inception, the Center has provided outpatient mental health services, counseling, forensic services, and advocacy to more than 25,000 children. The Center offers individual, group, and family therapy, along with specialized programs designed to address the effects of child abuse and neglect. Each year, approximately 1200 children receive counseling and/or forensic services on an outpatient basis, with no child being turned away due to a family's inability to pay. In addition to its direct services, the Center's work has a global impact. An animated video series, funded by the Barbara Sinatra Children's Center Foundation, has reached over 400 million worldwide and generated over 75 million single and classroom views on YouTube in the United States and aboard, with India as the second largest user behind the U.S. For more information, visit BarbaraSinatraChildrensCenter.org. Additional resources, including the Protect Yourself Rules and Teen Series Videos, can be found on the Fight Child Abuse YouTube channel at youtube.com/@fightchildabuse1913/videos or FightChildAbuse.org About the San Manuel Band of Mission Indians (SMBMI): The San Manuel Band of Mission Indians is a federally recognized Indian tribe located on the San Manuel Indian Reservation near Highland, California. San Manuel exercises its inherent sovereign right of self-governance and provides essential services for its citizens by building infrastructure, maintaining civil services, and promoting social, economic and cultural development. As the Indigenous people of the San Bernardino highlands, passes, valleys, mountains and high deserts, the Serrano people of San Manuel have called this area home since time immemorial and are committed to remaining a productive partner in the San Bernardino region. For more information, visit . About Loma Linda University Children's Hospital (LLUCH): The Children's Hospital is the only dedicated pediatric hospital in the vast geographic region of San Bernardino, Riverside, Inyo and Mono counties. With 348 beds dedicated just for kids, one of the largest Neonatal Intensive Care Units in the country and more than 100,000 children who come each year, LLUCH is a major pediatric teaching facility, known worldwide as the pioneer of neonatal heart transplantation. LLUCH is part of Loma Linda University Health – the umbrella organization encompassing Loma Linda University's eight professional schools, Loma Linda University Medical Center's six hospitals and more than 1,000 faculty physicians located across the Inland Empire in Southern California. A Seventh-day Adventist organization, Loma Linda University Health is a faith-based health system with a mission "to continue the teaching and healing ministry of Jesus Christ." SOURCE The Barbara Sinatra Children's Center WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

11 Jan 2024

·www.drugs.com

1999 to 2019 Saw Increase in Substance Use+CVD-Related Mortality

THURSDAY, Jan. 11, 2024 -- From 1999 to 2019, there was an increase in mortality related to substance use (SU) plus cardiovascular disease (CVD), according to a study published online Jan. 10 in the Journal of the American Heart Association . Abdul Mannan Khan Minhas, M.D., from the University of Mississippi Medical Center in Jackson, and colleagues identified SU+CVD-related deaths using Multiple Cause-of-Death Public Use record death certificates and examined trends in mortality. There were 636,572 SU+CVD-related deaths between 1999 and 2019. The researchers found the age-adjusted mortality rates were pronounced in men, in American Indian or Alaska Native individuals, in nonmetropolitan/rural areas, and for alcohol-related deaths (22.5, 37.7, 15.2, and 9.09 per 100,000 population, respectively). From 1999 to 2019, there was an increase observed in overall SU+CVD-related age-adjusted mortality rates from 9.9 to 21.4, with an average annual percent change of 4.0. Across all subgroups, there were increases seen in SU+CVD-related average annual percent changes, which were pronounced among women (4.8 percent) and for American Indian or Alaska Native individuals, younger individuals, nonmetropolitan areas, and cannabis and psychostimulant users. "We would like to see additional public health efforts to support comprehensive evaluation and management of substance use in the U.S. that includes clinician and patient education, as well as attention to socioeconomic factors that contribute to substance use," senior author Dmitry Abramov, M.D., from the Loma Linda University Medical Center in California, said in a statement. One author disclosed ties to the pharmaceutical industry. Abstract/Full Text Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions. Posted January 2024 More news resources FDA Medwatch Drug Alerts Daily MedNews News for Health Professionals New Drug Approvals New Drug Applications Drug Shortages Clinical Trial Results Generic Drug Approvals Subscribe to our newsletter Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

AHAClinical Study

12 Oct 2023

·www.prnewswire.com

Pulmonary Fibrosis Foundation Expands Care Center Network for PF Patients

Seven Sites Join Network as Clinical Associate Members CHICAGO, Oct. 12, 2023 /PRNewswire/ -- The Pulmonary Fibrosis Foundation (PFF) announced that seven medical centers have joined the PFF Care Center Network (CCN) as Clinical Associate members, a new membership option. Each of these Clinical Associates will collaborate with an existing Care Center Network site to help bring the resources of the PFF to even more people living with pulmonary fibrosis (PF) and interstitial lung disease (ILD). The Care Center Network includes 81 CCN sites and seven Clinical Associates in 39 states. Continue Reading (PRNewsfoto/The Pulmonary Fibrosis Foundation) "With the addition of seven Clinical Associate members, we are actively addressing the critical need to expand access for patients with PF and ILD to the resources available from the PFF as well as connecting more patients with providers committed to advancing the diagnosis and treatment of PF," said Dr. Sonye Danoff, PFF Senior Medical Advisor, PFF Care Center Network. "Our Clinical Associates will extend care to additional people living with these serious conditions and, in collaboration with CCN sites, they will provide patient education, clinical care and research opportunities including clinical trials." The newly designated Clinical Associate members of the PFF Care Center Network are: Avera Medical Group Pulmonary & Sleep Medicine (Sioux Falls, SD): Dr. Fady Jamous, Center Director Chest Medicine Associates Center for Interstitial Lung Disease (South Portland, ME): Dr. Meagan Moore, Center Director ChristianaCare (Newark, DE): Dr. Renee Dixon, Center Director Ochsner LSU Health Shreveport – Academic Medical Center(Shreveport, LA): Dr. Prangthip Charoenpong, Center Director StatCare Pulmonary (Knoxville, TN): Dr. Eric Weaver, Center Director St. Luke's University Health Network (Fountain Hill, PA): Dr. Douglas Corwin, Center Director University of New Mexico (Albuquerque, NM): Dr. Nour Ass'ad, Center Director Through the CCN, Care Centers and Clinical Associates collaborate to promote and provide quality care to those living with PF. Each Clinical Associate is paired with a current Care Center member so they may collaborate to expand and improve pulmonary fibrosis care. While Care Centers offer complete multi-disciplinary care on site, Clinical Associates may refer patients for procedures or services they are unable to offer. Clinical Associates actively participate in the CCN in working groups and committees, including the Nurse and Allied Health Network, which provides professional development and networking opportunities. More than 250,000 Americans are living with PF and ILD and over 50,000 new cases are diagnosed annually. There are over 200 types of ILD, which are characterized by varied amounts of inflammation, scarring, or both. This damages the ability of the lungs to absorb oxygen from the air. PF means scarring of the lung and can be seen in many types of ILD. The 88 sites now operating in the PFF Care Center Network are: Alabama University of Alabama at Birmingham (Birmingham) Arizona St. Joseph's Hospital (Phoenix) Banner University Medical Center (Phoenix ) University of Arizona (Tucson) California Cedars-Sinai Medical Center (Los Angeles) Center for Advanced Lung Disease at Keck Medicine of USC (Los Angeles) Loma Linda University Medical Center (Loma Linda) Stanford Health Center (Palo Alto) University of California at Davis Interstitial Lung Disease Program (Sacramento) University of California at Los Angeles (Los Angeles) University of California at San Diego (San, Diego) University of California at San Francisco (San Francisco) Colorado National Jewish Health (Denver) University of Colorado Anschutz Medical Campus (Aurora) Connecticut Yale School of Medicine (New Haven) Delaware **ChristianaCare Pulmonary Associates (Newark) NEW Florida Cleveland Clinic Florida (Weston) University of Florida (Gainesville) University of Miami (Miami) University of South Florida – Tampa General Hospital (Tampa) Georgia Emory University Hospital (Atlanta) Piedmont Healthcare (Atlanta) Illinois Loyola University Medical Center (Maywood) Northwestern Memorial Hospital (Chicago) Rush University Medical Center (Chicago) University of Chicago (Chicago) Indiana Indiana University (Bloomington) Iowa University of Iowa (Iowa City) Kansas The University of Kansas Hospital (Kansas City) Kentucky University of Kentucky Research Foundation (Lexington) University of Louisville School of Medicine (Louisville) Louisiana **Ochsner LSU Health Shreveport – Academic Medical Center (Shreveport) NEW Tulane University School of Medicine (New Orleans) Maine **Chest Medicine Associates Center for Interstitial Lung Disease (South Portland) NEW Maryland Johns Hopkins University (Baltimore) University of Maryland Medical Center (Baltimore) Massachusetts Beth Israel Deaconess Medical Center (Boston) Massachusetts General Hospital (Boston) St. Elizabeth's Medical Center (Boston) Michigan Corewell Health East (Royal Oak) Henry Ford Health System (Detroit) Spectrum Heath System (Grand Rapids) University of Michigan Health System (Ann Arbor) Minnesota University of Minnesota Medical Center (Minneapolis) Mayo Clinic (Rochester) Missouri St. Luke's Hospital (Chesterfield) Washington University School of Medicine (St. Louis) Nebraska Creighton University (Omaha) University of Nebraska Medical Center (Omaha) New Hampshire Dartmouth Health (Hanover, NH) New Mexico **University of New Mexico (Albuquerque) NEW New York Columbia University Medical Center (New York) New York University School of Medicine (New York) Stony Brook University Hospital (Stony Brook) University of Rochester Medical Center (Rochester) Weill-Cornell Medical Center (New York) North Carolina Duke University Medical Center (Durham) LeBauer Health Care at Cone Health (Greensboro) University of North Carolina Chapel Hill (Chapel Hill) Ohio Cleveland Clinic (Cleveland) The Ohio State University Wexner Medical Center (Columbus) University of Cincinnati Medical Center (Cincinnati) Oklahoma OU Health (Oklahoma City) Oregon The Oregon Clinic (Portland) Pennsylvania Penn State Milton S. Hershey Medical Center (Hershey) **St. Luke's University Health Network (Fountain Hill) NEW Temple Health (Philadelphia) Thomas Jefferson University Hospital (Philadelphia) University of Pennsylvania (Philadelphia) University of Pittsburgh (Pittsburgh) Rhode Island Rhode Island Hospital (Providence) South Carolina Medical University of South Carolina, (Charleston) South Dakota **Avera Medical Group Pulmonary & Sleep Medicine (Sioux Falls) NEW Tennessee **StatCare Pulmonary (Knoxville) NEW Vanderbilt University Medical Center (Nashville) Texas Baylor University Medical Center (Dallas) Houston Methodist Hospital (Houston) University of Texas Southwestern Medical Center (Dallas) University of Texas Health Science Center (Houston) The University of Texas Health Science Center (San Antonio) Utah University of Utah Health Care (Salt Lake City) Vermont The University of Vermont Medical Center (Burlington) Virginia Inova Fairfax Medical Campus (Falls Church) University of Virginia Health Systems (Charlottesville) VCU Health (Richmond) Washington University of Washington Medical Center (Seattle) Wisconsin Froedtert & the Medical College of Wisconsin Froedtert Hospital (Milwaukee) University of Wisconsin (Madison) **Clinical Associates About the Pulmonary Fibrosis Foundation The mission of the Pulmonary Fibrosis Foundation is to accelerate the development of new treatments and ultimately a cure for pulmonary fibrosis. Until this goal is achieved, the PFF is committed to advancing improved care of patients with PF and providing unequaled support and education resources for patients, caregivers, family members, and health care providers. The PFF has a four-star rating from Charity Navigator and is an accredited charity by the Better Business Bureau (BBB) Wise Giving Alliance. The Foundation has met all of the requirements of the National Health Council Standards of Excellence Certification Program® and has earned the Guidestar Platinum Seal of Transparency. For more information, visit pulmonaryfibrosis.org or call 844.TalkPFF (844.825.5733). Contact: Dorothy Coyle, 773-332-6201 SOURCE The Pulmonary Fibrosis Foundation

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