Randomized, Controlled, Multicenter Studies of the Effects of Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis

To investigate an economical and effective way to reduce the level of serum triglyceride in patients with hypertriglyceridemia-induced acute pancreatitis.

Start Date01 Nov 2017

Sponsor / Collaborator

Peking Union Medical College Hospital

[+10]

100 Clinical Results associated with Shenzhen Bao'an District Shajing People's Hospital

0 Patents (Medical) associated with Shenzhen Bao'an District Shajing People's Hospital

Literatures (Medical) associated with Shenzhen Bao'an District Shajing People's Hospital

01 Oct 2024·Cell Genomics

Genome-wide association study of maternal plasma metabolites during pregnancy

Article

Author: Chen, Fang ; Yang, Huanming ; Fu, Qingmei ; Li, Yan ; Wang, Yuan ; Wang, Jian ; Wang, Rong ; Rao, Weiqiao ; Yin, Ye ; Xie, Jiansheng ; Luo, Liqiong ; Hou, Guixue ; Wei, Fengxiang ; Zhang, Jing ; Ren, Jinghui ; Liu, Xinhong ; He, Xuelian ; Nie, Chao ; Wu, Linlin ; Jiang, Dan ; Yao, Jilong ; Liu, Siyang ; Chen, Yuanqing ; Gao, Ya ; Deng, Yuqing ; Li, Zilong ; Xiong, Likuan ; Zhou, Yun ; Xu, Xun ; Qiu, Xuemei ; Li, Linxuan ; Lin, Liang ; Su, Fengxia ; Liu, Zengyou ; Zhao, Weihua ; Huang, Liping ; Niu, Jianmin ; Zhu, Huanhuan ; Zhao, Mei ; Lan, Xianmei ; Zhao, Lijian ; Wu, Xiaoxia ; Kong, Nannan ; Lin, Shengmou ; Jin, Xin ; Liu, Siqi

Metabolites are key indicators of health and therapeutic targets, but their genetic underpinnings during pregnancy-a critical period for human reproduction-are largely unexplored. Using genetic data from non-invasive prenatal testing, we performed a genome-wide association study on 84 metabolites, including 37 amino acids, 24 elements, 13 hormones, and 10 vitamins, involving 34,394 pregnant Chinese women, with sample sizes ranging from 6,394 to 13,392 for specific metabolites. We identified 53 metabolite-gene associations, 23 of which are novel. Significant differences in genetic effects between pregnant and non-pregnant women were observed for 16.7%-100% of these associations, indicating gene-environment interactions. Additionally, 50.94% of genetic associations exhibited pleiotropy among metabolites and between six metabolites and eight pregnancy phenotypes. Mendelian randomization revealed potential causal relationships between seven maternal metabolites and 15 human traits and diseases. These findings provide new insights into the genetic basis of maternal plasma metabolites during pregnancy.

Hebei Yixue

Study on effects of calamine lotion and dexamethasone in the treatment of red hip of newborn

Author: Fang, Fang

Objective: In order to study the effects of calamine lotion and dexamethasone in the treatment of red hip of newborn.Method: 150 cases of red hip of newborn as exptl. subject.All the newborn were divided into two groups: Calamine lotion and dexamethasone of the experiment group, Tannic acid ointment of the therapeutic group.Result: Through different therapy, the ratio of effective in experiment group (96.00%) was higher than that in the control group (86.67%) (P < 0.05).Conclusion: Adopting calamine lotion & dexamethasone as the therapeutic drug are better than tannic acid ointment in the treatment of red hip of newborn.

Zhongguo Yiyao Daobao

Tracking survey of 15-year impaired glucose tolerance outcome of Shajing Street registered population in Shenzhen City

Author: Huang, Yan ; Han, Limin ; Le, Youqing

Objective To investigate the natural outcome and influencing factors of glucose tolerance reduction (IGT) in the developed rural urbanization area.Methods A 15-yr outcome tracking survey on 126 cases of IGT population confirmed by epidemiol. investigation in 2000 in Shajing Street of Shenzhen City was carried out.A unified survey form was adopted to investigate medical history, measure height, weight, waist circumference and blood pressure and calculate body mass index (BMI).Standard oral glucose tolerant test (OGTT) was used to measure fasting plasma glucose (FPG) and 2h postprandial plasma glucose (2hPG).Diabetes mellitus (DM) and glucose tolerance (IGT) were diagnosed according to the 1999 WHO diagnostic criteria.Obesity was diagnosed according to Chinese adult overweight and obesity prevention and control guidelines.Risk factors were analyzed by Logistic stepwise regression.Results Sixty-five cases converted to DM among 126 patients with IGT, the conversion rate was 51.6%, and the annual conversion rate was 3.44%.Compared with the patients converted to normal glucose tolerance (NGT group), age, BMI, FBG and 2hPG were significantly higher in DM group, and the differences were statistically significant (P < 0.05).Logistic stepwise regression anal. results showed that age (OR = 1.166, 95%CI 1.054-1.311, P = 0.0031), body mass index (BMI) (OR = 1.445, 95%CI 1.152-2.802, P = 0.0210) and 2hPG (OR = 3.015, 95%CI 1.166-7.709, P = 0.0214) were the risk factors of IGT converted to DM.Conclusion The main influencing factors of IGT converted to DM are age, obesity and 2hPG.Low conversion rate is related to low incidence of IGT and obesity in local.Lifestyle intervention is the most effective means of prevention, should strengthen the publicity and education of DM, maintain good cooking mode, strong motion, control overweight and obesity, in order to reduce the incidence of DM, which has a certain guidance meaning for DM prevention in economically developed rural urbanization area.

100 Deals associated with Shenzhen Bao'an District Shajing People's Hospital

100 Translational Medicine associated with Shenzhen Bao'an District Shajing People's Hospital

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