Beijing Tri-Prime Gene Pharmaceutical Co., Ltd.

A review.Interferon is the first line of innate defense against viruses infection.Interferon α1b is a major antiviral subtype of interferon family.SARS-CoV-2 have evolved several mechanisms to block interferon induction.Interferon α1b, has been approved for the antiviral clin. use for many years, showing strong in vitro antiviral activity against SARS-CoV-2.Preliminary clin. studies including type I interferon have showed critical pos. efficiency on COVID-19 treatment and prevention.A clin. trial with a larger cohort of infected patients that are randomized to treatment with interferon-α or to a placebo is ongoing.