The present study was conducted to evaluate the efficacy of organic acid blends as dietary antibiotic replacer in marine fish olive flounder, Paralichthys olivaceus.Fish averaging 3.5 ± 0.05 g (mean ± SD) were fed one of the four exptl. diets: (1) without antibiotic or organic acid (Control/CON); (2) with antibiotic-50 mg oxytetracycline per kg body weight per day (OTC); (3) with organic acid blend A-4 g/kg diet (OAA); and (4) with organic acid blend B-4 g/kg diet (OAB), for 10 wk.At the end of the experiment, total intestinal bacterial counts in fish-fed OAA, OAB and OTC were significantly lower than that of fish-fed CON diet (p < 0.05).Further, the group of fish-fed organic acid blends (OAA, OAB) or antibiotic (OTC)-supplemented diets exhibited lower intestinal Vibrio sp. counts compared with fish-fed CON diet.Disease challenge test with bacteria Edwardsiella tarda showed significantly lower cumulative mortality rates for the group of fish-fed OAA, OAB or OTC than that of fish-fed CON diet (p < 0.05).There were no neg. effects on the growth, serol. characteristics and proximate composition among the group of fish-fed different exptl. diets.Therefore, the present experiment demonstrates that blends of organic acid could be a promising alternative to dietary antibiotics for the preventive and/or curative health management in marine fish olive flounder aquaculture.