Delving into the Latest Updates on BioResearch Ireland with Synapse

Overview

Much work has focused on trying to identify markers in Helicobacter pylori that might allow the eventual disease outcome of an infection to be predicted.In this study we examined the cagA and vacA genotype, and Lewis status in a panel of 43 Irish H. pylori clin. isolates, and investigated a possible correlation with disease pathol.In addition, differences in the poly-(C) tract of the α(1,3)-fucosyltransferase gene were examined to identify a possible correlation with gene expression.Only three of 43 isolates were cagA-neg., whereas the remaining 40 isolates, independent of pathol., were cagA-pos.In all the strains we examined, the vacA signal-sequence was type s1a.For the vacA mid-region 12/43 isolates were type m1 and 31/43 isolates were type m2.These data, and examination of isolates from different pathol. groups, suggests that there is no correlation between virulence and vacA genotype in the Irish population of H. pylori isolates.Western blotting of whole cell lysates from 32 H. pylori isolates showed 3/32 displayed only the Le^x epitope, 12/32 only the Le^y, 13/32 both epitopes and 4/32 neither epitope.No apparent association between Lewis phenotype and disease pathol. was evident.A range of lengths of poly-(C) tract were observed in the α(1,3)-fucosyltransferase gene, however the length of the tract in an isolate did not correlate with the Lewis structures present.We conclude that future studies on H. pylori pathogenesis should not alone focus on the importance of mol. markers, but also on the host response, including genetic background and immune responsiveness.

100 Deals associated with BioResearch Ireland

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100 Translational Medicine associated with BioResearch Ireland

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Pipeline

Pipeline Snapshot as of 20 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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