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The loss of plasma antioxidants and the appearance of a pro-oxidant in plasma, exposed to a controlled oxidative stress, was monitored by the ABEL antioxidant test with peroxynitrite and Pholasin.This stress was applied using the radical initiators 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH).The appearance of a pro-oxidant, possibly a product of lipid peroxidation, was noted earlier from a donor and only when all the antioxidants in the sample had been consumed.The pro-oxidant formed earlier but was masked by antioxidants still present in the sample.As a higher antioxidant capacity, protected the plasma longer against lipid peroxidation, then enhancement of blood with antioxidants, during surgery, renal dialysis, and extracorporeal circulation, could protect against perfusion injury and/or complications of oxidative stress arising from oxidation of plasma constituents.

Pholasin monitors neutrophil degranulation and activation

Author: Knight, Jan ; McCafferty, Ann

This report summarizes some of the work currently underway with Pholasin, the photoprotein of Pholas dactylus, aimed identifying the species produced and events that occur during activation of the NADPH oxidase system and degranulation in the polymorphonuclear leukocyte (PMN).

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