Novel amino acid-based Poly(Ester Amide) copolymers (PEA)s were developed as coating materials for Drug-Eluting Stent (DES) applications.Reproducible mol. weight of PEAs was obtained under solution polymerization conditions.The resulting PEAs demonstrated a surface enzymic degradation profile by in vitro biodegradation experiment results, with min. non-specific hydrolysis degradationExcellent blood and tissue compatibility was obtained in both in vitro cell culture and preclin. porcine model studies.High elasticity (elongation > 300%) and good film forming properties make PEAs an excellent coating material for drug-eluting stent.Excellent twelve month follow-up for the First in Man clin. trial (NOBLESSE) using a functionalized PEA reveals the safety and efficacy of PEA coating material.Desired phys. polymer properties are obtained through the selecting of different components making up the polymer backbone.The programmable nature of PEA polymers makes it an excellent choice for different drug delivery applications.

Drug Delivery Technology

Inducing an immune response using a novel poly(ester-amide) co-polymer delivery platform

Author: Turnell, William G. ; Mendy, Jason ; Vassilev, Vassil P. ; Landis, Geoffrey C. ; Carpenter, Kenneth W. ; Minev, Boris R. ; Cantwell, Mark J. ; DeFife, Kristin M.

A formidable challenge confronting clin. immunol. is the development of synthetic vaccines that could offer advantages over traditional methods in safety, reliability, and cost.Appropriate delivery of protein and peptide antigens to the immune system has proved to be a major tech. hurdle.The search for tractable solutions to this problem has received significant impetus in recent years by the development of biodegradable polymers as delivery vehicles.In this article, the authors introduce poly(ester-amide) (PEA) co-polymers as a valuable addition to the current armory of antigen delivery vehicles.Furthermore, we present initial proof-of-concept experiments that demonstrate PEA co-polymers enhance cellular immunity, encompassing both MHC-I and MHC-II-restricted T-cell responses, in vitro and in vivo.The significance of these results is discussed in the context of the novel biochem. properties of PEA co-polymers.In particular, the enhanced shell-life compared with water/acid-degradable delivery vehicles, and freedom from adjuvant, make PEA co-polymers an exciting prospect as cost-effective and industrially feasible synthetic vaccines.

PMSE Preprints

Synthesis and characterization of biodegradable, amino acid based poly(ester urethanes)

Author: Ochoa, Catherine ; Achie, Franzwa ; Zhang, Huashi ; Da, Jie ; Gomurashvill, Zaza ; Knoy, Ryan ; De Rosales, Bibiane ; Angeles, Rosette ; Dominguez, Alan

A series of novel biodegradable poly(ester urethanes) were synthesized by active polycondensation method.The mol. weights of the synthesized polymer ranged from 48 to 124 kg/mol.Polymer thermal and tensile properties were affected by the chem. structure of the diols used to prepare bis(α-amino acid)-α,ω-alkylene diesters and di-p-nitrophenyl carbonate.

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