Delving into the Latest Updates on Qaam Pharmaceuticals LLC with Synapse

Overview

Author: Alzetani, Aiman ; Ethell, Douglas W ; Michalik, Daniel ; Counts, Scott E ; Elahi, Fanny ; Verma, Ajay ; Wunderlich, Hilary ; Rich, Steven A ; Hawkes, Cheryl A ; Brown, Christopher ; Kelly, Louise ; Piazza, Fabrizio ; Proulx, Steven T ; Fossati, Silvia ; Salib, Rami ; Snyder, Heather ; Koronyo-Hamaoui, Maya ; Dodart, Jean Cosme ; Wolters, Frank J ; Ismail, Ozama ; Haack, Mareike ; Mazer, Norman ; Agarwal, Nivedita ; Aldea, Roxana ; Carare, Roxana O ; de Leon, Mony

AbstractThis editorial summarizes advances from the Clearance of Interstitial Fluid and Cerebrospinal Fluid (CLIC) group, within the Vascular Professional Interest Area (PIA) of the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART). The overarching objectives of the CLIC group are to: (1) understand the age‐related physiology changes that underlie impaired clearance of interstitial fluid (ISF) and cerebrospinal fluid (CSF) (CLIC); (2) understand the cellular and molecular mechanisms underlying intramural periarterial drainage (IPAD) in the brain; (3) establish novel diagnostic tests for Alzheimer's disease (AD), cerebral amyloid angiopathy (CAA), retinal amyloid vasculopathy, amyloid‐related imaging abnormalities (ARIA) of spontaneous and iatrogenic CAA‐related inflammation (CAA‐ri), and vasomotion; and (4) establish novel therapies that facilitate IPAD to eliminate amyloid β (Aβ) from the aging brain and retina, to prevent or reduce AD and CAA pathology and ARIA side events associated with AD immunotherapy.

100 Deals associated with Qaam Pharmaceuticals LLC

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100 Translational Medicine associated with Qaam Pharmaceuticals LLC

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Glycopyrronium Bromide/Rivastigmine ( AChE x mAChRs )	Lewy Body Disease More	Discontinued
Donepezil/Glycopyrronium Bromide ( AChE x mAChRs )	Alzheimer Disease More	Pending