To determine curcumine in Qizhong Xiongdan capsules by HPLC, an anal. column (4.6 mm × 200 mm, 5 μm) packed with 5 μm Hypersil ODS was used, with acetonitrile-0.2% phosphoric acid (45:55) as mobile phase.The flow rate was 1 mL/min-1, the detection wavelength was 430 nm, and injection volume 10 μL.The calibration curve was linear in the range of 0.15-3.00 μg (r = 0.9999).The average recovery was 99.5%.The method is accurate and reliable, and can be used for quality control.