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19 Mar 2004·Angewandte Chemie (International ed. in English)Q1 · CHEMISTRY
Methotrexate Conjugates: A Molecular In Vivo Protein Tag
Q1 · CHEMISTRY
Article
Author: Lawrence W. Miller ; Julia Sable ; Philip Goelet ; Virginia W. Cornish ; Michael P. Sheetz
The labeling of proteins in living cells with fluorescent substituents is critical to the study of cell biol.A ligand-receptor approach based on the interaction between dihydrofolate reductase (DHFR) and methotrexate (Mtx) serves as a general method for labeling proteins with fluorescent or otherwise functional small mols. in vivo.
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