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A stability indicating RP-HPLC method was developed for simultaneous determination of netupitant and palonosetron in bulk and in combined tablet dosage form.The separation of netupitant and palonosetron was achieved within 6 min on an YMC Pack pro (150 mm x 4.6 mm, 5 μm particle size) C18 column using 0.1% orthophosphoric acid: Methanol (55:45 volume/volume) as the mobile phase.UV detection was carried out using wavelength 262 nm.The method showed adequate sensitivity concerning linearity, accuracy and precision over the range 450-1350 μg/mL and 0.75-2.25 μg/mL for netupitant and palonosetron, resp.Careful validation proved advantages of high sensitivity, accuracy, precision, selectivity, robust and suitability for quality control laboratoriesBoth the drugs were subjected to acid, alkali, oxidation, thermal and photolytic degradationThe degradation products produced in all the stress conditions were well resolved from the netupitant and palonosetron with significant differences in their retention time values.

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