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Tricog snaps up $9M funding for US expansion AI-based cardiac diagnosis solution provider Tricog has raised Rs 700 million ($8.5 million) in a Series B2 funding round led by Japanese institutions, Omron and Sony Innovation Fund. The round was also participated by the University of Tokyo Edge Capital, Inventus Partners, and Singapore's SG Innovate. The startup plans to use its fresh funds for its global expansion, particularly its entry into the United States market. Bangladeshi online pharmacy MedEasy acquires competitor MedEasy, an online pharmacy in Bangladesh, has acquired fellow startup Alchemy for an undisclosed sum. Through this acquisition, MedEasy is expanding its footprint by taking on Alchemy's existing customer base. It will also be integrating the latter's systems and processes into its own. Lunit integrates pathology AI into Indica Labs' platform US-based digital pathology solution provider Indica Labs and South Korean medical AI company Lunit have entered into an integration partnership. Based on a press statement, Lunit has integrated its AI pathology solutions, including the Lunit SCOPE PD-L1 for non-small cell lung cancer, into Indica Labs' HALO AP clinical image management platform. Their combined solution, which will enable pathologists and labs to "deliver faster, more accurate, and more reproducible answers," is now being used at precision oncology company Guardant Health. Coreline Soft enters Latin American market Coreline Soft has received clearance for its line of AI-powered medical imaging solutions, AVIEW, from the Brazilian Health Regulatory Agency or Anvisa. This marks the company's first entry into the Latin American market, following its earlier entry into other major markets, including the United States, Europe, Japan, Taiwan, Singapore, and Australia. Korean researchers develop wearable piezoelectric BP sensor A research team from the Korea Advanced Institute of Science and Technology has developed a wearable piezoelectric blood pressure sensor, which is said to be more sensitive compared to its PPG-based counterpart. According to a press release, ultrathin piezoelectric sensors exhibit "conformal contact" with the skin to collect accurate blood pressure from subtle pulses. A clinical trial at St. Mary’s Hospital of the Catholic University of Korea has validated the accuracy of the piezoelectric sensor, recording errors within ±5 mmHg and a standard deviation under 8 mmHg for both systolic and diastolic blood pressure. The reseachers have also embedded the sensor into a watch to enable continuous BP monitoring.

July 28, 2022 12:00 UTC − Achieved Second Quarter 2022 Global Net Product Revenues of $214 Million for ONPATTRO®, GIVLAARI®, and OXLUMO® (33% Growth vs. Same Period Last Year) – − Received FDA Approval of AMVUTTRA™ (vutrisiran) for the Treatment of the Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis in Adults – − Expects to Report Topline Results from APOLLO-B Phase 3 Trial of Patisiran in Patients with ATTR Amyloidosis with Cardiomyopathy Within the Next Three Weeks – – Reiterated 2022 Financial Guidance, Including Combined Net Product Revenues of $870-$930 Million – CAMBRIDGE, Mass.--(BUSINESS WIRE)-- Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), the leading RNAi therapeutics company, today reported its consolidated financial results for the second quarter ended June 30, 2022 and reviewed recent business highlights. “We’re pleased with our second quarter results which delivered strong growth in both patient demand and product revenues. A notable achievement in the quarter was the recent approval of AMVUTTRA, which becomes our fifth RNAi therapeutic approved in under four years, and marks our continued progress in building a multi-product TTR franchise. We’re excited to have initiated the U.S. launch and look forward to potential additional global approvals and subsequent rollout,” said Yvonne Greenstreet, MBChB, Chief Executive Officer of Alnylam. “We are also eager for a number of important milestones over the rest of the year, including topline results from the APOLLO-B Phase 3 study of patisiran in ATTR amyloidosis with cardiomyopathy patients, which we’ve announced today are expected within the next three weeks. Additionally, we plan to continue to advance our robust pipeline, with clinical data expected across several prevalent disease programs in NASH, HBV, gout, and early-onset Alzheimer’s disease with ALN-APP, our first investigational RNAi therapeutic targeting a CNS disorder. We believe the first half of 2022 has been one of steady progress and commercial execution, and we look forward to the many important milestones through the end of the year, moving us further along our path toward achieving our Alnylam P5x25 goals.” Second Quarter 2022 and Recent Significant Corporate Highlights Commercial Performance TTR Franchise: ONPATTRO® (patisiran) & AMVUTTRA™ (vutrisiran) Achieved global net product revenues for ONPATTRO for the second quarter of 2022 of $153 million, representing a 12% increase compared to Q1 2022. Attained over 2,400 hATTR amyloidosis patients with polyneuropathy worldwide on commercial ONPATTRO treatment as of June 30, 2022, up from over 2,200 commercial patients as of March 31, 2022, representing 9% quarterly growth. Received 133 Start Forms in the U.S. for AMVUTTRA from launch through July 22, 2022 with 34% representing patients new to Alnylam and 66% representing patients switching from ONPATTRO. GIVLAARI® (givosiran) Achieved global net product revenues for the second quarter of 2022 of $45 million, representing a 28% increase compared to Q1 2022. Attained over 420 patients worldwide on commercial GIVLAARI treatment as of June 30, 2022, up from over 400 commercial patients as of March 31, 2022, representing 5% quarterly growth. OXLUMO® (lumasiran) Achieved global net product revenues for the second quarter of 2022 of $15 million, representing a 2% increase compared to Q1 2022. Attained over 200 patients worldwide on commercial OXLUMO treatment as of June 30, 2022, up from over 160 commercial patients as of March 31, 2022, representing 25% quarterly growth. Leqvio® (inclisiran) Launch in the U.S. and other markets is ongoing, with focus on patient onboarding, removing access hurdles and enhancing medical education. R&D Highlights Vutrisiran (the non-proprietary name for AMVUTTRA), a subcutaneously administered RNAi therapeutic in development for the treatment of ATTR amyloidosis and Stargardt Disease Received FDA approval of AMVUTTRA for the treatment of the polyneuropathy of hereditary transthyretin-mediated amyloidosis in adults. Received a positive opinion from the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) recommending approval of vutrisiran for the treatment of hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) in adult patients with stage 1 or stage 2 polyneuropathy. Reported new 18-month results from exploratory cardiac endpoints from the HELIOS-A Phase 3 study in hATTR amyloidosis patients with polyneuropathy. Lumasiran (the non-proprietary name for OXLUMO), for the treatment of primary hyperoxaluria type 1 (PH1), and in development for the treatment of recurrent kidney stone disease Presented new results from the ILLUMINATE-A Phase 3 study in patients with PH1. Presented new results from the 12-month analysis of the ILLUMINATE-B Phase 3 open-label pediatric study in patients less than six years of age with PH1. Presented new results from the ILLUMINATE-C Phase 3 study in patients with advanced PH1. Cemdisiran, in development for the treatment of complement-mediated diseases, in collaboration with Regeneron. Reported positive topline results from the Phase 2 study in patients with immunoglobulin A nephropathy (IgAN). Alnylam is working with Regeneron to finalize plans for the Phase 3 clinical development of cemdisiran in IgAN, with the potential to initiate a program by late 2022. Fitusiran, in development for the treatment of hemophilia A or B with and without inhibitors, in collaboration with Sanofi. Sanofi presented positive data from the Phase 3 ATLAS-PPX study evaluating the efficacy and safety of once-monthly fitusiran (80 mg) in adults and adolescents with severe hemophilia A or B who were previously treated with prior factor or bypassing agent (BPA) prophylaxis. The study met the primary endpoint and demonstrated fitusiran prophylaxis significantly reduced bleeding episodes compared to prior factor or BPA prophylaxis. Early- and mid-stage investigational RNAi therapeutic pipeline programs and RNAi platform Published preclinical results in Nature Biotechnology based on novel conjugate technology facilitating delivery of siRNA to the CNS and other extrahepatic tissues. Vir Biotechnology presented new results from its ongoing Phase 2 clinical trial of ALN-HBV02 (VIR-2218), as well as preclinical data evaluating ALN-HBV02 in combination with VIR-3434, in patients with chronic hepatitis B virus infection. Initiated a Phase 1 study of ALN-XDH in patients with gout. Published research findings in Nature Communications identifying mutations in the INHBE gene associated with protection against abdominal obesity and metabolic syndrome. Upcoming Events Alnylam announces today that it expects to report topline results from the pivotal APOLLO-B Phase 3 study of patisiran in ATTR amyloidosis patients with cardiomyopathy within the next three weeks. In addition, the Company announces today that it plans to present results from the Phase 2 study of cemdisiran in patients with IgAN at the 18th European Meeting on Complement in Human Disease (EMCHD) being held August 26-29, 2022 in Bern, Switzerland. In addition, in mid- and late-2022, Alnylam intends to: Launch vutrisiran in the EU, assuming a favorable adoption of the CHMP opinion by the European Commission, for the treatment of hATTR amyloidosis patients with polyneuropathy. Report topline results from Part B of the Phase 1 study of ALN-HSD in patients with NASH. Report results on a biannual dose regimen for vutrisiran. Initiate a Phase 3 study of vutrisiran in patients with Stargardt Disease. File an Investigational New Drug (IND) application and initiate a Phase 1 study for ALN-TTRsc04 in healthy volunteers. Complete enrollment in the Phase 2 study of lumasiran in patients with recurrent renal stones. Complete enrollment in the KARDIA-2 Phase 2 study of zilebesiran (at or around year-end). Vir Biotechnology plans to report additional results from its Phase 2 study of ALN-HBV02 in combination with VIR-3434 in patients with chronic HBV infection in the second half of 2022. Report preliminary results from the Phase 1 study of ALN-APP in patients with early-onset Alzheimer's disease. Report preliminary results from the Phase 1 study of ALN-XDH in patients with gout. Financial Results for the Quarter Ended June 30, 2022 Financial Highlights Three Months Ended June 30, (in thousands, except per share amounts) 2022 2021 Net product revenues $ 213,515 $ 160,811 Net revenue from collaborations $ 9,025 $ 59,395 Royalty revenue $ 2,278 $ 347 GAAP Operating loss $ (191,686 ) $ (146,160 ) Non-GAAP Operating loss $ (161,215 ) $ (114,082 ) GAAP Other expense, net $ (82,987 ) $ (42,171 ) Non-GAAP Other expense, net $ (81,890 ) $ (37,737 ) GAAP Net loss $ (277,402 ) $ (189,559 ) Non-GAAP Net loss $ (245,834 ) $ (153,047 ) GAAP Net loss per common share – basic and diluted $ (2.29 ) $ (1.61 ) Non-GAAP Net loss per common share – basic and diluted $ (2.03 ) $ (1.30 ) Net Product Revenues Three Months Ended June 30, Year over Year % Growth (in thousands, except percentages) 2022 2021 As Reported At CER* ONPATTRO net product revenues $ 153,428 $ 113,839 35 % 42 % GIVLAARI net product revenues 45,150 30,630 47 % 53 % OXLUMO net product revenues 14,937 16,342 (9 )% (4 )% Total $ 213,515 $ 160,811 33 % 40 % * CER = Constant Exchange Rate, representing growth calculated as if the exchange rates had remained unchanged from those used in the second quarter 2021. CER is a Non-GAAP measure. Net product revenues increased 33% at actual currency during the second quarter of 2022, as compared to the prior year, and 40% at CER. The increase is primarily due to increased patients on ONPATTRO and GIVLAARI. Net Revenues from Collaborations Net revenues from collaborations decreased 85% during the second quarter of 2022, as compared to the prior year, primarily due to a decrease in revenue from our collaboration with Regeneron resulting from the timing of reimbursable activities. Second Quarter 2022 Expenses Three Months Ended June 30, (in thousands) 2022 2021 GAAP research and development expenses $ 205,712 $ 182,635 Non-GAAP research and development expenses $ 195,074 $ 169,549 GAAP selling, general and administrative expenses $ 169,984 $ 145,323 Non-GAAP selling, general and administrative expenses $ 150,151 $ 126,331 Research & Development (R&D) Expenses GAAP and Non-GAAP R&D expenses increased during the second quarter of 2022, as compared to the prior year, primarily due to increased early development and study activities, increased employee headcount and other expenses to support our development activities. Selling, General & Administrative (SG&A) Expenses GAAP and Non-GAAP SG&A expenses increased during the second quarter of 2022, as compared to the prior year, primarily due to increased employee headcount and other expenses to support our commercial portfolio. Other Financial Highlights GAAP other expense, net, increased during the second quarter of 2022, as compared to the prior year, primarily due to an approximate $32 million increase in the fair value of our development derivative liability and an increase in interest expenses of approximately $9 million related to additional draws on our term loan facility. Cash, cash equivalents and marketable securities were $2.11 billion as of June 30, 2022, compared to $2.44 billion as of December 31, 2021, with the decrease primarily due to our operating loss in the second quarter of 2022. A reconciliation of our GAAP to non-GAAP results for the current quarter is included in the tables of this press release. 2022 Financial Guidance1 Full year 2022 financial guidance is reiterated and consists of the following: Combined net product revenues for ONPATTRO, GIVLAARI, OXLUMO and AMVUTTRA $870 million - $930 million Net revenues from collaborations and royalties $175 million - $225 million GAAP R&D and SG&A expenses $1,620 million - $1,700 million Non-GAAP R&D and SG&A expenses2 $1,390 million - $1,450 million 1 Guidance utilizes April 18, 2022 FX rates of: 1 EUR = 1.08 USD; 1 GBP = 1.31 USD; 1 CHF = 1.06 USD; 1 CAD = 0.79 USD; 1 USD = 126 JPY. 2 Primarily excludes $230-$250 million of stock-based compensation expense from estimated GAAP R&D and SG&A expenses. Use of Non-GAAP Financial Measures This press release contains non-GAAP financial measures, including expenses adjusted to exclude certain non-cash expenses and non-recurring gains outside the ordinary course of the Company’s business and revenue growth excluding the impact of changes in foreign exchange rates. These measures are not in accordance with, or an alternative to, GAAP, and may be different from non-GAAP financial measures used by other companies. The items included in GAAP presentations but excluded for purposes of determining non-GAAP financial measures for the periods presented in this press release are stock-based compensation expenses and realized and unrealized (gains) losses on marketable equity securities. The Company has excluded the impact of stock-based compensation expense, which may fluctuate from period to period based on factors including the variability associated with performance-based grants for stock options and restricted stock units and changes in the Company’s stock price, which impacts the fair value of these awards. The Company has excluded the impact of the realized and unrealized (gains) losses on marketable equity securities because the Company does not believe these adjustments accurately reflect the performance of the Company’s ongoing operations for the period in which such gains or losses are reported, as their sole purpose is to adjust amounts on the balance sheet. Percentage changes in revenue growth at CER are presented excluding the impact of changes in foreign currency exchange rates for investors to understand the underlying business performance. The current period’s foreign currency revenue values are converted into U.S. dollars using the average exchange rates from the prior period. The Company believes the presentation of non-GAAP financial measures provides useful information to management and investors regarding the Company’s financial condition and results of operations. When GAAP financial measures are viewed in conjunction with non-GAAP financial measures, investors are provided with a more meaningful understanding of the Company’s ongoing operating performance and are better able to compare the Company’s performance between periods. In addition, these non-GAAP financial measures are among those indicators the Company uses as a basis for evaluating performance, allocating resources and planning and forecasting future periods. Non-GAAP financial measures are not intended to be considered in isolation or as a substitute for GAAP financial measures. A reconciliation between GAAP and non-GAAP measures is provided later in this press release. Conference Call Information Management will provide an update on the Company and discuss second quarter 2022 results as well as expectations for the future via conference call on Thursday, July 28, 2022 at 8:30 am ET. To access the call, please register online at . Participants are requested to register at a minimum 15 minutes before the start of the call. A replay of the call will be available two hours after the call and archived on the same web page for six months. A live audio webcast of the call will be available on the Investors section of the Company’s website at . An archived webcast will be available on the Alnylam website approximately two hours after the event. About ONPATTRO® (patisiran) ONPATTRO is an RNAi therapeutic that was approved in the United States and Canada for the treatment of the polyneuropathy of hATTR amyloidosis in adults. ONPATTRO is also approved in the European Union, Switzerland and Brazil for the treatment of hATTR amyloidosis in adults with Stage 1 or Stage 2 polyneuropathy, and in Japan for the treatment of hATTR amyloidosis with polyneuropathy. ONPATTRO is an intravenously administered RNAi therapeutic targeting transthyretin (TTR) and should be administered via a healthcare professional. It is designed to target and silence TTR messenger RNA, thereby blocking the production of TTR protein before it is made. ONPATTRO blocks the production of TTR in the liver, reducing its accumulation in the body’s tissues in order to halt or slow down the progression of the polyneuropathy associated with the disease. For more information about ONPATTRO, including the full U.S. Prescribing Information, visit ONPATTRO.com. About GIVLAARI® (givosiran) GIVLAARI is an RNAi therapeutic targeting aminolevulinic acid synthase 1 (ALAS1) approved in the United States and Brazil for the treatment of adults with acute hepatic porphyria (AHP). GIVLAARI is also approved in the European Union for the treatment of AHP in adults and adolescents aged 12 years and older. In the pivotal study, givosiran was shown to significantly reduce the rate of porphyria attacks that required hospitalizations, urgent healthcare visits or intravenous hemin administration at home compared to placebo. GIVLAARI is Alnylam’s first commercially available therapeutic based on its Enhanced Stabilization Chemistry ESC-GalNAc conjugate technology to increase potency and durability. GIVLAARI is administered via subcutaneous injection once monthly at a dose based on actual body weight and should be administered by a healthcare professional. GIVLAARI works by specifically reducing elevated levels of ALAS1 messenger RNA (mRNA), leading to reduction of toxins associated with attacks and other disease manifestations of AHP. For more information about GIVLAARI, including the full U.S. Prescribing Information, visit GIVLAARI.com. About OXLUMO® (lumasiran) OXLUMO is an RNAi therapeutic targeting hydroxyacid oxidase 1 (HAO1) for the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary oxalate levels in pediatric and adult patients. HAO1 encodes glycolate oxidase (GO), an enzyme upstream of the disease-causing defect in PH1. OXLUMO works by degrading HAO1 messenger RNA and reducing the synthesis of GO, which inhibits hepatic production of oxalate – the toxic metabolite responsible for the clinical manifestations of PH1. In the pivotal ILLUMINATE-A study, OXLUMO was shown to significantly reduce levels of urinary oxalate relative to placebo, with the majority of patients reaching normal or near-normal levels. Injection site reactions (ISRs) were the most common drug-related adverse reaction. In the ILLUMINATE-B pediatric Phase 3 study, OXLUMO demonstrated an efficacy and safety pro to that observed in ILLUMINATE-A. OXLUMO utilizes Alnylam’s Enhanced Stabilization Chemistry (ESC)-GalNAc conjugate technology designed to increase potency and durability. OXLUMO is administered via subcutaneous injection once monthly for three months, then once quarterly thereafter at a dose based on actual body weight. For patients who weigh less than 10 kg, ongoing dosing remains monthly. OXLUMO should be administered by a healthcare professional. For more information about OXLUMO, including the full U.S. Prescribing Information, visit OXLUMO.com. About AMVUTTRA™ (vutrisiran) AMVUTTRA™ (vutrisiran) is an RNAi therapeutic approved in the United States for the treatment of the polyneuropathy of hereditary transthyretin-mediated (hATTR) amyloidosis in adults. It is a double‑stranded small interfering RNA (siRNA) that targets mutant and wild‑type transthyretin (TTR) messenger RNA (mRNA). Using Alnylam’s Enhanced Stabilization Chemistry (ESC)-GalNAc-conjugate delivery platform, AMVUTTRA is designed for increased potency and high metabolic stability to allow for subcutaneous injection once every three months (quarterly). Results from the pivotal HELIOS-A Phase 3 study demonstrate AMVUTTRA rapidly reduces serum TTR levels, has the potential to reverse neuropathy impairment relative to baseline and improves other key measures of disease burden relative to external placebo in patients with the polyneuropathy of hATTR amyloidosis. For more information about AMVUTTRA, including the full U.S. Prescribing Information, visit AMVUTTRA.com. About LNP Technology Alnylam has licenses to Arbutus Biopharma LNP intellectual property for use in RNAi therapeutic products using LNP technology. About RNAi RNAi (RNA interference) is a natural cellular process of gene silencing that represents one of the most promising and rapidly advancing frontiers in biology and drug development today. Its discovery has been heralded as “a major scientific breakthrough that happens once every decade or so,” and was recognized with the award of the 2006 Nobel Prize for Physiology or Medicine. By harnessing the natural biological process of RNAi occurring in our cells, a new class of medicines known as RNAi therapeutics is now a reality. Small interfering RNA (siRNA), the molecules that mediate RNAi and comprise Alnylam's RNAi therapeutic platform, function upstream of today’s medicines by potently silencing messenger RNA (mRNA) – the genetic precursors – that encode for disease-causing or disease pathway proteins, thus preventing them from being made. This is a revolutionary approach with the potential to transform the care of patients with genetic and other diseases. About Alnylam Pharmaceuticals Alnylam (Nasdaq: ALNY) has led the translation of RNA interference (RNAi) into a whole new class of innovative medicines with the potential to transform the lives of people afflicted with rare and prevalent diseases with unmet need. Based on Nobel Prize-winning science, RNAi therapeutics represent a powerful, clinically validated approach yielding transformative medicines. Since its founding 20 years ago, Alnylam has led the RNAi Revolution and continues to deliver on a bold vision to turn scientific possibility into reality. Alnylam’s commercial RNAi therapeutic products are ONPATTRO® (patisiran), GIVLAARI® (givosiran), OXLUMO® (lumasiran), AMVUTTRA™ (vutrisiran), and Leqvio® (inclisiran) being developed and commercialized by Alnylam’s partner, Novartis. Alnylam has a deep pipeline of investigational medicines, including multiple product candidates that are in late-stage development. Alnylam is executing on its “Alnylam P5x25” strategy to deliver transformative medicines in both rare and common diseases benefiting patients around the world through sustainable innovation and exceptional financial performance, resulting in a leading biotech profile. Alnylam is headquartered in Cambridge, MA. For more information about our people, science and pipeline, please visit and engage with us on Twitter at @Alnylam, on LinkedIn, or on Instagram. Alnylam Forward Looking Statements Various statements in this release concerning Alnylam’s expectations, plans, aspirations and goals, including, without limitation, our aspiration to become a leading biotech company and the planned achievement of our “Alnylam P5x25” strategy, the launch of AMVUTTRA in the U.S. for the treatment of the polyneuropathy of hATTR amyloidosis in adults, and the ongoing review and potential approval of vutrisiran by other regulatory authorities, the expected timing of topline data from the APOLLO-B Phase 3 clinical study, the achievement of additional pipeline milestones and data, including relating to ongoing clinical studies of vutrisiran, zilebesiran, lumasiran, cemdisiran, ALN-HBV02 (Vir 2218), ALN-HSD, ALN-APP and ALN-XDH, the initiation of a Phase 3 clinical study for vutrisiran in Stargardt disease and the filing of an IND for ALN-TTRsc04, the expected range of net product revenues and net revenues from collaborations and royalties for 2022, and the expected range of aggregate annual GAAP and non-GAAP R&D and SG&A expenses for 2022, constitute forward-looking statements for the purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. Actual results and future plans may differ materially from those indicated by these forward-looking statements as a result of various important risks, uncertainties and other factors, including, without limitation: the direct or indirect impact of the COVID-19 global pandemic or any future pandemic on Alnylam’s business, results of operations and financial condition and the effectiveness or timeliness of Alnylam’s efforts to mitigate the impact of the pandemic; the potential impact of the recent leadership transition on Alnylam’s ability to attract and retain talent and to successfully execute on its “Alnylam P5x25” strategy; Alnylam's ability to discover and develop novel drug candidates and delivery approaches and successfully demonstrate the efficacy and safety of its product candidates, including patisiran; the pre-clinical and clinical results for its product candidates; actions or advice of regulatory agencies and Alnylam’s ability to obtain and maintain regulatory approval for its product candidates, as well as favorable pricing and reimbursement; successfully launching, marketing and selling its approved products globally; delays, interruptions or failures in the manufacture and supply of its product candidates or its marketed products; obtaining, maintaining and protecting intellectual property; Alnylam’s ability to successfully expand the indication for ONPATTRO, AMVUTTRA or OXLUMO in the future; Alnylam's ability to manage its growth and operating expenses through disciplined investment in operations and its ability to achieve a self-sustainable financial pro the future without the need for future equity financing; Alnylam’s ability to maintain strategic business collaborations; Alnylam's dependence on third parties for the development and commercialization of certain products, including Novartis, Regeneron and Vir; the outcome of litigation; the potential impact of a current government investigation and the risk of future government investigations; and unexpected expenditures; as well as those risks more fully discussed in the “Risk Factors” filed with Alnylam's most recent Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) and in its other SEC filings. In addition, any forward-looking statements represent Alnylam's views only as of today and should not be relied upon as representing its views as of any subsequent date. Alnylam explicitly disclaims any obligation, except to the extent required by law, to update any forward-looking statements. This release discusses investigational RNAi therapeutics and uses of previously approved RNAi therapeutics in development and is not intended to convey conclusions about efficacy or safety as to those investigational therapeutics or uses. There is no guarantee that any investigational therapeutics or expanded uses of commercial products will successfully complete clinical development or gain health authority approval. ALNYLAM PHARMACEUTICALS, INC. CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS (In thousands, except per share amounts) (Unaudited) Three Months Ended Six Months Ended June 30, 2022 June 30, 2021 June 30, 2022 June 30, 2021 Statements of Operations Revenues: Net product revenues $ 213,515 $ 160,811 $ 400,387 $ 296,580 Net revenues from collaborations 9,025 59,395 34,970 101,192 Royalty revenue 2,278 347 2,720 347 Total revenues 224,818 220,553 438,077 398,119 Operating costs and expenses: Cost of goods sold 34,038 30,256 57,495 53,279 Cost of collaborations and royalties 6,770 8,499 18,940 16,538 Research and development 205,712 182,635 375,605 368,534 Selling, general and administrative 169,984 145,323 324,455 292,182 Total operating costs and expenses 416,504 366,713 776,495 730,533 Loss from operations (191,686 ) (146,160 ) (338,418 ) (332,414 ) Other (expense) income: Interest expense (42,609 ) (33,416 ) (84,971 ) (65,931 ) Other (expense) income, net (40,378 ) (8,755 ) (90,640 ) 10,739 Total other expense, net (82,987 ) (42,171 ) (175,611 ) (55,192 ) Loss before income taxes (274,673 ) (188,331 ) (514,029 ) (387,606 ) Provision for income taxes (2,729 ) (1,228 ) (3,714 ) (2,244 ) Net loss $ (277,402 ) $ (189,559 ) $ (517,743 ) $ (389,850 ) Net loss per common share - basic and diluted $ (2.29 ) $ (1.61 ) $ (4.29 ) $ (3.32 ) Weighted-average common shares used to compute basic and diluted net loss per common share 120,896 117,772 120,646 117,428 ALNYLAM PHARMACEUTICALS, INC. RECONCILIATION OF SELECTED GAAP MEASURES TO NON-GAAP MEASURES (In thousands, except per share amounts) (Unaudited) Three Months Ended Six Months Ended June 30, 2022 June 30, 2021 June 30, 2022 June 30, 2021 Reconciliation of GAAP to Non-GAAP research and development: GAAP Research and development $ 205,712 $ 182,635 $ 375,605 $ 368,534 Less: Stock-based compensation expenses (10,638 ) (13,086 ) (22,255 ) (37,461 ) Non-GAAP Research and development $ 195,074 $ 169,549 $ 353,350 $ 331,073 Reconciliation of GAAP to Non-GAAP selling, general and administrative: GAAP Selling, general and administrative $ 169,984 $ 145,323 $ 324,455 $ 292,182 Less: Stock-based compensation expenses (19,833 ) (18,992 ) (37,509 ) (50,307 ) Non-GAAP Selling, general and administrative $ 150,151 $ 126,331 $ 286,946 $ 241,875 Reconciliation of GAAP to Non-GAAP operating loss: GAAP Operating loss $ (191,686 ) $ (146,160 ) $ (338,418 ) $ (332,414 ) Add: Stock-based compensation expenses 30,471 32,078 59,764 87,768 Non-GAAP Operating loss $ (161,215 ) $ (114,082 ) $ (278,654 ) $ (244,646 ) Reconciliation of GAAP to Non-GAAP Other (expense) income: GAAP Total other expense, net $ (82,987 ) $ (42,171 ) $ (175,611 ) $ (55,192 ) Add: Unrealized loss on marketable equity securities 1,097 4,434 32,258 (42,582 ) Non-GAAP Other expense, net $ (81,890 ) $ (37,737 ) $ (143,353 ) $ (97,774 ) Reconciliation of GAAP to Non-GAAP net loss: GAAP Net loss $ (277,402 ) $ (189,559 ) $ (517,743 ) $ (389,850 ) Add: Stock-based compensation expenses 30,471 32,078 59,764 87,768 Add (Less): Realized and unrealized loss (gain) on marketable equity securities 1,097 4,434 32,258 (42,582 ) Non-GAAP Net loss $ (245,834 ) $ (153,047 ) $ (425,721 ) $ (344,664 ) Reconciliation of GAAP to Non-GAAP net loss per common share-basic and diluted: GAAP Net loss per common share - basic and diluted $ (2.29 ) $ (1.61 ) $ (4.29 ) $ (3.32 ) Add: Stock-based compensation expenses 0.25 0.27 0.50 0.75 Add (Less): Realized and unrealized loss (gain) on marketable equity securities 0.01 0.04 0.27 (0.36 ) Non-GAAP Net loss per common share - basic and diluted $ (2.03 ) $ (1.30 ) $ (3.53 ) $ (2.93 ) Please note that the figures presented above may not sum exactly due to rounding ALNYLAM PHARMACEUTICALS, INC. RECONCILIATION OF GAAP TO NON-GAAP PRODUCT REVENUE GROWTH AT CONSTANT CURRENCY (Unaudited) June 30, 2022 Three Months Ended Six Months Ended ONPATTRO net product revenue growth, as reported 35 % 35 % Less: Impact of foreign currency translation 7 6 ONPATTRO net product revenue growth at constant currency 42 % 41 % GIVLAARI net product revenue growth, as reported 47 % 45 % Less: Impact of foreign currency translation 6 5 GIVLAARI net product revenue growth at constant currency 53 % 50 % OXLUMO net product revenue growth, as reported (9 )% 16 % Less: Impact of foreign currency translation 5 6 OXLUMO net product revenue growth at constant currency (4 )% 22 % Total net product revenue growth, as reported 33 % 35 % Less: Impact of foreign currency translation 7 6 Total net product revenue growth at constant currency 40 % 41 % ALNYLAM PHARMACEUTICALS, INC. CONDENSED CONSOLIDATED BALANCE SHEETS (In thousands, except per share amounts) (Unaudited) June 30, 2022 December 31, 2021 ASSETS Current assets: Cash and cash equivalents $ 575,558 $ 819,975 Marketable debt securities 1,504,154 1,548,617 Marketable equity securities 30,901 66,972 Accounts receivable, net 142,271 198,571 Inventory 88,976 86,363 Prepaid expenses and other current assets 129,778 88,078 Total current assets 2,471,638 2,808,576 Property, plant and equipment, net 508,201 501,958 Operating lease right-of-use assets 223,921 231,675 Restricted investments 49,390 40,891 Other assets 77,267 60,204 Total assets $ 3,330,417 $ 3,643,304 LIABILITIES AND STOCKHOLDERS’ EQUITY Current liabilities: Accounts payable $ 52,418 $ 73,426 Accrued expenses 421,243 395,174 Operating lease liability 41,236 40,548 Deferred revenue 114,292 149,483 Liability related to the sale of future royalties 28,496 37,079 Total current liabilities 657,685 695,710 Operating lease liability, net of current portion 272,016 281,347 Deferred revenue, net of current portion 175,341 152,360 Long-term debt 677,723 675,697 Liability related to the sale of future royalties, net of current portion 1,214,311 1,151,024 Other liabilities 157,301 98,963 Total liabilities 3,154,377 3,055,101 Commitments and contingencies (Note 13) Stockholders’ equity: Preferred stock, $0.01 par value per share, 5,000 shares authorized and no shares issued and outstanding as of June 30, 2022 and December 31, 2021 — — Common stock, $0.01 par value per share, 250,000 shares authorized; 120,992 shares issued and outstanding as of June 30, 2022; 120,182 shares issued and outstanding as of December 31, 2021 1,210 1,202 Additional paid-in capital 6,172,990 6,058,453 Accumulated other comprehensive loss (42,224 ) (33,259 ) Accumulated deficit (5,955,936 ) (5,438,193 ) Total stockholders’ equity 176,040 588,203 Total liabilities and stockholders’ equity $ 3,330,417 $ 3,643,304 This selected financial information should be read in conjunction with the consolidated financial statements and notes thereto included in Alnylam’s Annual Report on Form 10-K which includes the audited financial statements for the year ended December 31, 2021.

The global thalassemia market is projected to grow at a favorable rate from 2021 to 2031 (forecast period). The expanding population, increased need for improved curative gene treatments, and increased awareness of existing treatment choices are the primary aspects expected to drive the worldwide thalassemia market during the forecast period. As per the World Health Organization (WHO), thalassemia affects around 4.4 out of every 10,000 live births worldwide. Moreover, around 5% of the world's population has a polymorphism in the beta or alpha region of the hemoglobin molecule. Furthermore, an increase in the development of pipeline pharmaceuticals and innovative therapeutics, together with research and development, is projected to boost the global thalassemia market. In addition, rising investments in the healthcare sector are likely to create revenue-generation opportunities in thalassemia market throughout the forecast period. Thalassemia Market – Competitive Landscape Leading players in the thalassemia market are Bluebird Bio, Novartis AG, Bellicum Pharmaceuticals, Acceleron Pharma, Inc., ApoPharma Inc, IONIS Pharmaceuticals, SG Pharma Pvt. Lmt, Kiadis Pharma, and Lonza Group Ltd. Market players are adopting marketing methods such as technological developments, collaborations, acquisitions, investments, and R&D activities to widen their international presence. Moreover, several innovative gene treatments with improved mechanisms of action are now in late-stage studies to meet the significant unmet demand for thalassemia therapy. GET BROCHURE OF THE REPORT Thalassemia Market – Trends and Opportunities The global thalassemia market is expected to gain from a spike in the number of clinical trials for thalassemia treatment alternatives. Moreover, the increase in thalassemia prevalence and the development of thalassemia pipeline drugs are projected to fuel the thalassemia market growth. Furthermore, factors such as the expanding market for blood transfusion therapy and bone marrow transplant, an uptick in the number of transfusion-dependent patients, and the development of accessible therapeutic solutions for thalassemia are anticipated to boost the global thalassemia market. In addition, an upsurge in healthcare spending, a rise in demand for improved curative gene therapy, and an increase in expenditure on stem cell therapy research are some of the main factors expected to promote the growth of the thalassemia market during the forecast period. The hospital segment is projected to witness significant growth in the worldwide thalassemia market during the forecast period. This is mostly due to an increase in hospital admissions for thalassemia therapy. Moreover, the increased incidence of thalassemia is expected to fuel segmental market growth. The labs segment, on the other hand, is likely to experience considerable growth during the projection period due to rising public awareness of thalassemia therapy. GET TABLE OF CONTENT OF THE REPORT Thalassemia Market – Regional Landscape The North America thalassemia market is anticipated to develop during the forecast period. The high incidence of thalassemia patients in the area, the existence of prominent players, and the developed healthcare infrastructure are some of the key reasons expected to boost the regional market growth. Moreover, positive government efforts and a rise in the number of research collaborations are likely to fuel market expansion. The United States is projected to be the largest revenue generator in thalassemia market due to increased knowledge of the disorder, a growing number of populations with the thalassemia carrier gene, and an increase in birth rates due to genetic heterogeneity within the population. The thalassemia market in Asia Pacific is likely to expand during the forecast period. The rising number of thalassemia patients and higher government spending on the healthcare system are the primary factors anticipated to propel the regional market in the upcoming years. Moreover, developing countries such as China and India are expected to contribute to the thalassemia market in Asia Pacific during the forecast period. GET DISCOUNT ON THE LATEST REPORT TMR Research has rich experience in developing state-of-the-art reports for a wide array of markets and sectors. The brilliance of the experts at TMR Research and their alacrity to conduct thorough research and create phenomenal reports makes TMR Research better than others. 5-Point Growth Formula The 5-point growth formula developed by TMR Research provides an insight to the stakeholders and CXOs about the current situation in the market. The growth formula makes the report a perfect companion for the stakeholders and CXOs. 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The reports are constantly updated with the latest trends so that the stakeholders and CXOs can derive benefits from the trends and generate good revenues. Regional Assessment Demography forms an important part of the growth pattern of all the markets. Diving deep into the demographics enables maximum output from specific areas. The TMR Research team assesses every region and picks out the vital points that have a large impact on the growth of a market. Industrial Analogy The analysts at TMR Research conduct an all-round analysis on the competitive landscape of the market. The observations recorded by the analysts are added to the reports so that every stakeholder gets a glimpse of the competitive scenario and frame their business plans according to the situation. COVID-19 Impact The COVID-19 outbreak has changed the growth projections of numerous sectors and businesses. The analysts at TMR Research have conducted a conscientious survey on the markets after the pandemic struck. The analysts have put forth their brilliant and well-researched opinions in the report. The opinions will help the stakeholders to plan their strategy accordingly. The reports offer answers to the top 7 questions that revolve around the growth of the market What are the diverse growth parameters influencing the market? Which regions will contribute largely to the growth of the market What are the recent innovations and technological advancements in the market? What are the emerging trends across the market? How has COVID-19 affected the market? What will be the post-pandemic scenario of the market? What are the major threats that will dent the growth prospects of the market? About TMR Research TMR Research is a premier provider of customized market research and consulting services to business entities keen on succeeding in today’s supercharged economic climate. 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