Objective To study the therapeutic effect of Gushen Jianpi Huashi Formula combined with Candesartan Cilexetil on diabetic nephropathy. Methods Ninety-four patients with diabetic nephropathy admitted to our hospital from Jan. 2018 to March 2019 were divided into control group and observation group according to random number table method: 47 patients in control group and 47 patients in observation group. The control group was treated with Candesartan CilexetilTablets orally. The observation group was treated with Gushen Jianpi Huashi Formula on the basistreatment of the control group. Fourteen days was a course of treatment. Two groupswere treated for 6 courses. The therapeutic effects of two groups were compared. The levels of proteinuria, urinary microprotein and β-2 microglobulin before and after treatment were compared. The scores of TCM symptoms, serum creatinine and urea nitrogen levels before and after treatment were compared. The levels of inflammatory factors IL-6, IL-18 and TNF-α before and after treatment were compared between the two groups. Results The results showed that the total effective rate of the observation group was 70.21% (33/47), and that of the control group was 44.68% (21/47). The total effective rate of the observation group was significantly higher than that of the control group (P<0.05). The levels of 24-h proteinuria, 24-h urinary microprotein and beta-2 microglobulin in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). Facial edema, mental fatigue and limb pain in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The serum levels of creatinine and urea nitrogen in the observation group were lower than those in the control group, and the difference was statistically significant (P<0.05). The levels of IL-6, IL-18 and TNF-αin the observation group were significantly lower than those in the control group (P<0.05). Conclusion In conclusion, Gushen Jianpi Huashi Formula combined with Candesartan Cilexetil has a prominent therapeutic effect on diabetic nephropathy. Compared with western medicine alone, it fully embodies the advantages of combination of Chinese and Western medicine in the treatment of diabetic nephropathy. By reducing the levels of inflammatory factors in patients, reducing urinary albumin indicators, and delaying the development of kidney damage, the process improves the clin. symptoms and is worthy of clin. application.